Resveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets

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dc.contributor.authorRocha, K. K. R. [UNESP]
dc.contributor.authorSouza, G. A. [UNESP]
dc.contributor.authorEbaid, Geovana Xavier [UNESP]
dc.contributor.authorSeiva, F. R. F. [UNESP]
dc.contributor.authorCataneo, A. C. [UNESP]
dc.contributor.authorNovelli, E. L. B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:33:07Z
dc.date.available2014-05-20T15:33:07Z
dc.date.issued2009-06-01
dc.description.abstractThe beneficial action of moderate wine consumption is increasingly being attributed to resveratrol (trans-3,4',5-trihydroxystilbene). To test the safety of resveratrol use as a dietary supplement, 24 mate Wistar rats were initially divided into three groups: (C, n = 6) was given standard chow and water; (R. n = 6) received standard chow and 6 mg/l resveratrol in its drinking water (1 mg/kg/day), and (HFD, n = 12) received high-fat diet and water. In order to more appropriately study the effects of resveratrol on high-fat diet, after 30 days of treatments, HFD-rats were divided into two subgroups (n = 6/group):(HFD) remained receiving high-fat diet and water: (HFD-R) given high-fat diet and 6 mg/l resveratrol in its drinking water (11 mg/kg/day). The total experimental period was 45 days. The resveratrol dose took into account its average concentration in wine, the time variability of wine ingestion, and so of resveratrol consumption in humans. HFD-rats had hyperglycaemia, dyslipidemia, increased serum oxidized-LDL (ox-LDL) and hepatic oxidative stress. Comparing HFD-R and HFD-rats, resveratrol improved lipid profile and glucose level, enhanced superoxide dismutase, thus reducing ox-LDL and hepatic oxidative stress. Resveratrol, in standard-fed-rats reduced glutathione-antioxidant defense system and enhanced hepatic lipid hydroperoxide. In conclusion, based on the results of this single dose preliminary study with resveratrol in the drinking water of male Wistar rats for 30 days, it may be concluded that resveratrol may have beneficial effects in high-fat diets (e.g. ox-LDL, decreased serum and hepatic oxidative stress), but not in standard-fed diets (effects produced include enhanced hepatic oxidative stress). Further studies are indicated. (C) 2009 Elsevier Ltd. All rights reserved.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Med, Dept Clin & Cardiol, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Biol Sci, Dept Chem & Biochem, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Med, Dept Clin & Cardiol, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1362-1367
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2009.03.010
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 47, n. 6, p. 1362-1367, 2009.
dc.identifier.doi10.1016/j.fct.2009.03.010
dc.identifier.issn0278-6915
dc.identifier.lattes8459042567486109
dc.identifier.urihttp://hdl.handle.net/11449/41839
dc.identifier.wosWOS:000266418300046
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectResveratrolen
dc.subjectLiveren
dc.subjectOxidative stressen
dc.subjectOxidized-LDLen
dc.subjectHigh-fat dieten
dc.titleResveratrol toxicity: Effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat dietsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes8459042567486109
unesp.author.orcid0000-0002-7461-8773[4]
unesp.author.orcid0000-0003-2330-9337[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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