Gastrointestinal cytomegalovirus disease in renal transplant recipients: A case series

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dc.contributor.authorde Andrade, Luís G.M. [UNESP]
dc.contributor.authorRodrigues, Maria A.M. [UNESP]
dc.contributor.authorRomeiro, Fernando Gomes [UNESP]
dc.contributor.authorCarvalho, Maria F.C. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:26:23Z
dc.date.available2014-05-27T11:26:23Z
dc.date.issued2012-03-01
dc.description.abstractThe purpose of this article was to report a series of 23 renal transplant recipients with histologically proven and immunohistochemically confirmed cytomegalovirus (CMV) lesions in the gastrointestinal tract (GIT) and to assess the risk factors associated with severe disease/mortality. CMV patients (n=23) were allocated into two groups: those who died (n=6) and those considered cured (n=17). Overall mortality rate was 26% (6/23). Initial symptoms suggestive of lower GIT involvement were observed in all death cases and in 35.3% of those cured (p=0.01). Enterorrhagia was seen in 83.3% of the patients who died. Death risk increased twofold (RR 2 [1.13-3.52], p=0.01) when symptoms of lower GIT involvement were initially observed and sixfold when enterrohagia was present (RR 6 [1.1-35.9], p=0.001). Among death cases, mean time at diagnosis was significantly more distant (2002±2.9×2008±1.6, p=0.04). The difference in mortality rates seen as service practices changed along the years demonstrates the importance of early diagnosis. © 2011 John Wiley & Sons A/S.en
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School, Botucatu
dc.description.affiliationDepartment of Pathology Botucatu Medical School, Botucatu
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School, Botucatu
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School, Botucatu
dc.format.extent345-350
dc.identifierhttp://dx.doi.org/10.1111/j.1399-0012.2011.01514.x
dc.identifier.citationClinical Transplantation, v. 26, n. 2, p. 345-350, 2012.
dc.identifier.doi10.1111/j.1399-0012.2011.01514.x
dc.identifier.issn0902-0063
dc.identifier.issn1399-0012
dc.identifier.scopus2-s2.0-84859852220
dc.identifier.urihttp://hdl.handle.net/11449/73206
dc.language.isoeng
dc.relation.ispartofClinical Transplantation
dc.relation.ispartofjcr1.518
dc.relation.ispartofsjr0,767
dc.relation.ispartofsjr0,767
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCytomegalovirus
dc.subjectGastrointestinal
dc.subjectRenal transplantation
dc.subjectadult
dc.subjectcytomegalovirus infection
dc.subjectfemale
dc.subjectgastrointestinal infection
dc.subjectgraft recipient
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectintestinal bleeding
dc.subjectkidney transplantation
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmortality
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjectsymptom
dc.subjectAdult
dc.subjectCytomegalovirus Infections
dc.subjectFemale
dc.subjectGastrointestinal Diseases
dc.subjectHumans
dc.subjectImmunocompromised Host
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOpportunistic Infections
dc.subjectRisk Factors
dc.titleGastrointestinal cytomegalovirus disease in renal transplant recipients: A case seriesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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