The median raphe nucleus in anxiety revisited

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dc.contributor.authorAndrade, Telma Gonçalves Carneiro Spera de [UNESP]
dc.contributor.authorZangrossi, Helio
dc.contributor.authorGraeff, Frederico G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Neurosci & Behav INeC
dc.date.accessioned2014-12-03T13:11:37Z
dc.date.available2014-12-03T13:11:37Z
dc.date.issued2013-12-01
dc.description.abstractAlthough the role of the median raphe nucleus (MRN) in the regulation of anxiety has received less attention than that of the dorsal raphe nucleus (DRN) there is substantial evidence supporting this function. Reported results with different animal models of anxiety in rats show that whereas inactivation of serotonergic neurons in the MRN causes anxiolysis, the stimulation of the same neurons is anxiogenic. In particular, studies using the elevated T-maze comparing serotonergic interventions in the MRN and in the DRN indicate that the former affect only the inhibitory avoidance task, which has been related to generalized anxiety. In contrast, similar operations in the DRN change both the inhibitory avoidance and the one-way escape task, the latter being representative of panic disorder. Simultaneous injections of 5-HT-acting drugs in the MRN and in the dorsal hippocampus (DH) suggest that the MRN-DH pathway mediates the regulatory function of the MRN in anxiety. Overall, the results discussed in this review point to a relevant role of the MRN in the regulation of anxiety, but not panic, through the 5-HT pathway that innervates the DH.en
dc.description.affiliationSao Paulo State Univ, UNESP, Dept Biol Sci, Assis, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Pharmacol, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationInst Neurosci & Behav INeC, Ribeirao Preto, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Dept Biol Sci, Assis, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao de Amparo ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas de Ribeirao Preto (FAEPA)
dc.description.sponsorshipIdFAEPA: 05/11
dc.format.extent1107-1115
dc.identifierhttp://dx.doi.org/10.1177/0269881113499208
dc.identifier.citationJournal Of Psychopharmacology. London: Sage Publications Ltd, v. 27, n. 12, p. 1107-1115, 2013.
dc.identifier.doi10.1177/0269881113499208
dc.identifier.issn0269-8811
dc.identifier.urihttp://hdl.handle.net/11449/113338
dc.identifier.wosWOS:000326859700005
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Psychopharmacology
dc.relation.ispartofjcr4.738
dc.relation.ispartofsjr1,939
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMedian raphe nucleusen
dc.subjectdorsal raphe nucleusen
dc.subjecthippocampusen
dc.subjectserotoninen
dc.subjectanxiety and panicen
dc.titleThe median raphe nucleus in anxiety revisiteden
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Ltd
unesp.author.orcid0000-0002-7918-8776[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assispt

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