Bladder augmentation in rabbits with anionic collagen membrane, with or without urotelial preservation. Cistometric and hystologic evaluation

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dc.contributor.authorLepper, Fábio G. O. [UNESP]
dc.contributor.authorRamos, Tamara M.
dc.contributor.authorTrindade Filho, José C. S.
dc.contributor.authorVale, Fabiana R.
dc.contributor.authorPadovani, Carlos R.
dc.contributor.authorGoissis, Gilberto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:29:37Z
dc.date.available2015-12-07T15:29:37Z
dc.date.issued2002
dc.description.abstractThe use of bowel segments to perform bladder augmentation is associated with several metabolic and surgical complications. A great variety of synthetic materials, biodegradable or not, have been tested. Collagen-based biomaterials have shown effectiveness for the regeneration and obtainment of a functional bladder. Assess the functional and histological response of the rabbit bladder to anionic collagen membrane (ACM), either when it is anastomosed to the bladder or it is placed onto bladder after vesicomyectomy. In 15 male rabbit a partial cystectomy was performed. After 4 weeks they were divided in 3 groups. Group 1 (G1) - bladder augmentation with ACM. Group 2 (G2) ACM is placed onto bladder after vesicomyectomy. Group 3 (G3) control group. Maximal bladder capacity (MBC) and weight were assessed with 4 (M1), 8 (M2) and 12 (M3) weeks after partial cystectomy. In M3 was performed the sacrifice and extraction of the bladder and kidneys for anatomopathologic study. There were neither bladder stones, nor implant extrusion in M3. There was a significant increase in MBC in G1 and G2 (p<0.05), but no statistical differences in G3 (p=0.35). There is no significant difference comparing G1 and G2. In M3, both groups have shown a bigger MBC than G3 (p<0.05). The microscopic assessment showed an inflammatory reaction in the bladder augmented, with urothelium preserved. The ACM was effective for the increase of MBC. The bladders with preservation of the urothelium have shown an extensive inflammatory process.en
dc.description.affiliationDepartment of Urology, Botucatu School of Medicine, State University of São Paulo (UNESP), Botucatu, São Paulo, Brazil. jcarlos@fmb.unesp.br
dc.description.affiliationUnespDepartment of Urology, Botucatu School of Medicine, State University of São Paulo (UNESP), Botucatu, São Paulo, Brazil. jcarlos@fmb.unesp.br
dc.format.extent464-470
dc.identifierhttp://www.brazjurol.com.br/september_october_2002/Lepper_ing_464_470.htm
dc.identifier.citationInternational Braz J Urol : Official Journal Of The Brazilian Society Of Urology, v. 28, n. 5, p. 464-469, 2002.
dc.identifier.issn1677-5538
dc.identifier.pubmed15748374
dc.identifier.urihttp://hdl.handle.net/11449/130827
dc.language.isoeng
dc.publisherInternational Braz J Urol : Official Journal Of The Brazilian Society Of Urology
dc.relation.ispartofInternational Braz J Urol : Official Journal Of The Brazilian Society Of Urology
dc.relation.ispartofjcr0.976
dc.relation.ispartofsjr0,367
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectBladderen
dc.subjectTransplanten
dc.subjectCollagenen
dc.subjectRabbit modelen
dc.subjectUrodynamicsen
dc.titleBladder augmentation in rabbits with anionic collagen membrane, with or without urotelial preservation. Cistometric and hystologic evaluationen
dc.typeArtigo
unesp.author.lattes8727897080522289[5]
unesp.author.orcid0000-0002-7719-9682[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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