Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid

Página do item simplificado
dc.contributor.authorDos Santos, Michel David
dc.contributor.authorAlmeida, Maria Camila [UNESP]
dc.contributor.authorLopes, Norberto Peporine
dc.contributor.authorDe Souza, Glória Emília Petto
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:22:01Z
dc.date.available2014-05-27T11:22:01Z
dc.date.issued2006-11-01
dc.description.abstractPhenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100 mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100 mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200 mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA. © 2006 Pharmaceutical Society of Japan.en
dc.description.affiliationUniversity of São Paulo Faculty of Pharmaceutical Sciences of Ribeirão Preto Campus Universitário da USP, Avenida do Café s/n, Ribeirão Preto-SP 14040-903
dc.description.affiliationUniversity of São Paulo Medical School of Ribeirão Preto Campus Universitário da USP, Avenida dos Bandeirantes 3900, Ribeirão Preto-SP 14049-900
dc.description.affiliationSão Paulo State University at Rio Claro Department of Zoology, Avenida 24A, 1515, Rio Claro-SP 13506-900
dc.description.affiliationUnespSão Paulo State University at Rio Claro Department of Zoology, Avenida 24A, 1515, Rio Claro-SP 13506-900
dc.format.extent2236-2240
dc.identifierhttp://dx.doi.org/10.1248/bpb.29.2236
dc.identifier.citationBiological and Pharmaceutical Bulletin, v. 29, n. 11, p. 2236-2240, 2006.
dc.identifier.doi10.1248/bpb.29.2236
dc.identifier.issn0918-6158
dc.identifier.issn1347-5215
dc.identifier.scopus2-s2.0-33750632133
dc.identifier.urihttp://hdl.handle.net/11449/69193
dc.language.isoeng
dc.relation.ispartofBiological and Pharmaceutical Bulletin
dc.relation.ispartofjcr1.694
dc.relation.ispartofsjr0,626
dc.relation.ispartofsjr0,626
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAnalgesic
dc.subjectAnti-inflammatory
dc.subjectCarrageenin
dc.subjectChlorogenic acid
dc.subjectFormalin
dc.subjectLipopolysaccharide (LPS)
dc.subjectchlorogenic acid
dc.subjectlipopolysaccharide
dc.subjectpolyphenol derivative
dc.subjectanalgesic activity
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectantinociception
dc.subjectantioxidant activity
dc.subjectantipyretic activity
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug effect
dc.subjectdrug inhibition
dc.subjectfever
dc.subjectinflammation
dc.subjectmale
dc.subjectnonhuman
dc.subjectpain assessment
dc.subjectpaw edema
dc.subjectrat
dc.subjectAdministration, Oral
dc.subjectAnalgesics
dc.subjectAnalgesics, Non-Narcotic
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectCarrageenan
dc.subjectChlorogenic Acid
dc.subjectDisease Models, Animal
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Evaluation, Preclinical
dc.subjectEdema
dc.subjectFever
dc.subjectFlavonoids
dc.subjectFormaldehyde
dc.subjectHindlimb
dc.subjectInflammation
dc.subjectLipopolysaccharides
dc.subjectMale
dc.subjectMolecular Structure
dc.subjectPain
dc.subjectPhenols
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTime Factors
dc.titleEvaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic aciden
dc.typeArtigo
dcterms.licensehttps://www.jstage.jst.go.jp/pub/html/AY04S120_en.html
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

Arquivos

Coleções

Artigos - Zoologia - IBRC