New molecular variants of hypothalamus-pituitary-gonad axis genes and their association with early puberty phenotype in Bos taurus indicus (Nellore)

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dc.contributor.authorMilazzotto, M. P.
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorNichi, M.
dc.contributor.authorMiranda-Neto, T.
dc.contributor.authorTeixeira, L. A.
dc.contributor.authorFerraz, J. B. S.
dc.contributor.authorEler, J. P.
dc.contributor.authorCampagnari, F. [UNESP]
dc.contributor.authorGarcia, J. F. [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCFM Agropecuaria Ltda
dc.date.accessioned2014-05-20T14:00:45Z
dc.date.available2014-05-20T14:00:45Z
dc.date.issued2008-04-01
dc.description.abstractEndocrine system plays a major role in the control of reproductive functions which are regulated by the hypothalamus-pituitary-gonad axis and its interactions. FSH and LH receptor genes are expressed at the gonads and GnRH receptor gene is expressed at the anterior pituitary gland. Misense mutations of the FSH, LH or GnRH receptors, activating or inactivating their functions in mammals, are potentially useful to allow the understanding of the role of this group of gonadotropins in reproductive phenotypes as early puberty and birth interval length. In the present study, polymorphisms in bovine exon 11 and 3'UTR of LHR, exon 10 and 3'UTR of FSHR and GnRHR genes were characterized with some of them resulting in changes in the aminoacidic chain. These polymorphic sites were found in a Bos taurus indicus (Nellore) female population by means of PCR-SSCP and DNA sequencing. Association between nucleotidic/aminoacidic changes and early puberty were determined by Chi-square analysis. It was found association between FSHR 3'UTR polymorphisms at position 2181, 2248 and 2249 bp and early puberty phenotype (p < 0.05). The presence of these new molecular markers might be considered in further studies to validate its correlation with early puberty or other reproduction associated phenotypes in cattle breeds. (C) 2007 Published by Elsevier B.V.en
dc.description.affiliationUniv São Paulo, Dept Anim Reprod, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Biol, S J Rio Preto, Brazil
dc.description.affiliationCFM Agropecuaria Ltda, S J Rio Preto, Brazil
dc.description.affiliationUniv São Paulo, Dept Basic Sci, Pirassununga, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Anim Prod & Hlth, Aracatube, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Biol, S J Rio Preto, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Anim Prod & Hlth, Aracatube, Brazil
dc.format.extent274-279
dc.identifierhttp://dx.doi.org/10.1016/j.livsci.2007.05.006
dc.identifier.citationLivestock Science. Amsterdam: Elsevier B.V., v. 114, n. 2-3, p. 274-279, 2008.
dc.identifier.doi10.1016/j.livsci.2007.05.006
dc.identifier.issn1871-1413
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.urihttp://hdl.handle.net/11449/21463
dc.identifier.wosWOS:000255514500015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLivestock Science
dc.relation.ispartofjcr1.204
dc.relation.ispartofsjr0,730
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLHRen
dc.subjectFSHRen
dc.subjectGnRHRen
dc.subjectearly pubertyen
dc.subjectBovineen
dc.subjectcattleen
dc.titleNew molecular variants of hypothalamus-pituitary-gonad axis genes and their association with early puberty phenotype in Bos taurus indicus (Nellore)en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7991082362671212[2]
unesp.author.orcid0000-0001-5693-6148[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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