Histopathological Condition of the Remaining Tissues after Endodontic Infection of Rat Immature Teeth

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dc.contributor.authorTobias Duarte, Paulo Carvalho [UNESP]
dc.contributor.authorGomes-Filho, Joao Eduardo [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorMarcal Mazza Sundefeld, Maria Lucia [UNESP]
dc.contributor.authorTadahiroWayama, Marcelo [UNESP]
dc.contributor.authorLodi, Carolina Simonetti [UNESP]
dc.contributor.authorDezan Júnior, Eloi [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:44Z
dc.date.available2014-12-03T13:10:44Z
dc.date.issued2014-04-01
dc.description.abstractIntroduction: Recently, case reports have shown that immature teeth diagnosed with necrotic pulp and periapical periodontitis can be repaired through a regenerative endodontic procedure. True regeneration depends on the presence of stem cells in the remaining vital tissues. The aim of this study was to evaluate the histologic condition of the pulp tissue, root apical papilla, and periapical tissues after inducing endodontic infection in immature rat teeth for different periods. Methods: This study evaluated 18 first upper rat molars (36 roots). Periapical lesions were induced and were confirmed radiographically, and the animals were divided into 3 groups according to the days of pulp exposure for endodontic infection induction: 30, 60, and 90 days. Histologic analysis was performed in 5 different areas (ie, cervical, middle, and apical root canal thirds; the apical papilla; and the periapex surrounding the apical papilla). Results: At 30 days, one third of the specimens still showed vital but intensely inflamed pulp tissue in the apical third and vital apical papilla with varying degrees of inflammation. After 60 days, the results were similar with respect to the apical pulp tissue and apical papilla. Completely necrotic pulp tissue in the space canal and vital apical papilla were observed in about 67% of the cases after 90 days. Conclusions: Vital pulp tissue was observed in the apical third until 60 days and in the vital apical papilla until 90 days of infection in a rat model.en
dc.description.affiliationUniv Estadual Paulista, Aracatuba Sch Dent, Dept Endodont, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Aracatuba Sch Dent, Dept Basic Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Aracatuba Sch Dent, Dept Pediat & Social Dent, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Aracatuba Sch Dent, Dept Endodont, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Aracatuba Sch Dent, Dept Basic Sci, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Aracatuba Sch Dent, Dept Pediat & Social Dent, Sao Paulo, Brazil
dc.format.extent538-542
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2013.09.015
dc.identifier.citationJournal Of Endodontics. New York: Elsevier Science Inc, v. 40, n. 4, p. 538-542, 2014.
dc.identifier.doi10.1016/j.joen.2013.09.015
dc.identifier.issn0099-2399
dc.identifier.lattes4408095517346846
dc.identifier.lattes8813777272581972
dc.identifier.lattes9235743081667362
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.urihttp://hdl.handle.net/11449/112473
dc.identifier.wosWOS:000334647400015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Endodontics
dc.relation.ispartofjcr2.886
dc.relation.ispartofsjr1,585
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectEndodontic infectionen
dc.subjectimmature nonvital teethen
dc.subjectperiapical lesionen
dc.subjectregenerationen
dc.titleHistopathological Condition of the Remaining Tissues after Endodontic Infection of Rat Immature Teethen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4408095517346846[3]
unesp.author.lattes8813777272581972
unesp.author.lattes9235743081667362
unesp.author.orcid0000-0003-0707-1912[1]
unesp.author.orcid0000-0003-4859-0583[3]
unesp.author.orcid0000-0003-2348-7846[8]
unesp.author.orcid0000-0001-5994-2287[2]
unesp.author.orcid0000-0002-5699-6578[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Restauradora - FOA
Artigos - Ciências Básicas - FOA
Artigos - Odontologia Infantil e Social - FOA