Investigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimurium

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dc.contributor.authorNogueira, MEI
dc.contributor.authorPassoni, M. H.
dc.contributor.authorBiso, F. I.
dc.contributor.authorLongo, M. D.
dc.contributor.authorCardoso, CRP
dc.contributor.authordos Santos, L. C.
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:36Z
dc.date.available2014-05-20T13:24:36Z
dc.date.issued2006-04-01
dc.description.abstractMelcanpodium divaricatian is a member of the Asteraccae and in Brazil is known as false-calendula, its flowers being used in anti-inflammatory preparations, substituting the true calendula or marigold (Calendula officinalis L.). The flower extract was investigated for mutagenic and antimutagenic effect in the Sahnonella/microsome assay. The tested extract was not mutagenic in the strains TA100, TA98, TA97a and TA102 and decreased the mutagenicity of aflatoxin B1, benzo(a)pyrene and daunomycin. Chlorophyll and triterpenes were detected in the extract, and they might have contributed to the observed effect. Our data suggest that these medicinal plants possess cancer chemopreventive properties. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Chem, BR-14801970 Araraquara, SP, Brazil
dc.format.extent361-366
dc.identifierhttp://dx.doi.org/10.1016/j.tiv.2005.08.012
dc.identifier.citationToxicology In Vitro. Oxford: Pergamon-Elsevier B.V., v. 20, n. 3, p. 361-366, 2006.
dc.identifier.doi10.1016/j.tiv.2005.08.012
dc.identifier.issn0887-2333
dc.identifier.lattes7501930236496670
dc.identifier.urihttp://hdl.handle.net/11449/7684
dc.identifier.wosWOS:000236987100014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofToxicology in Vitro
dc.relation.ispartofjcr3.105
dc.relation.ispartofsjr0,931
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSalmonella typhimuriumpt
dc.subjectantimutagenic activitypt
dc.subjectMelampodium divaricationpt
dc.subjecttriterpenespt
dc.titleInvestigation of genotoxic and antigenotoxic activities of Melampodium divaricatum in Salmonella typhimuriumen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0001-6554-7689[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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