Synthesis, characterization, crystal structure, and biological studies of vanadium complexes with glycolic acid

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dc.contributor.authorGuilherme, Luciana R. [UNESP]
dc.contributor.authorMassabni, Antonio C. [UNESP]
dc.contributor.authorCuin, Alexandre [UNESP]
dc.contributor.authorOliveira, Luiz A. A. [UNESP]
dc.contributor.authorCastellano, Eduardo E.
dc.contributor.authorHeinrich, Tassiele A.
dc.contributor.authorCosta-Neto, Claudio M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:33:31Z
dc.date.available2014-05-20T15:33:31Z
dc.date.issued2009-01-01
dc.description.abstractSynthesis, characterization, crystal structure, and biological studies of two complexes with glycolic acid are described. The solid complexes were formulated as K2[VO(C2H2O3)(C2H3O3)2] H2O (1) and K2[{VO2(C2H2O3)}2] (2) and characterized by X-ray studies, Fourier transform infrared spectroscopy (FTIR), Electron paramagnetic resonance (EPR), and magnetic susceptibility. Conversion of 1 to 2 was studied in aqueous solution by UV-Vis spectroscopy and in the solid state by diffuse reflectance spectroscopy. Complex 2 contains dinuclear [{VO2(C2H2O3)}2]2- anions in which glycolate(2-) is a five-membered chelating ring formed by carboxylate and -hydroxy groups. The geometry around the vanadium in 2 was interpreted as intermediate between a trigonal bipyramid and a square pyramid. Vanadium(IV) is pentacoordinate in 1 as a distorted square pyramid. Complex 1 contains a vanadyl group (V=O) surrounded by two oxygens from deprotonated carboxylate and hydroxy groups forming a five-membered ring. Two oxygens from different glycolates(1-) are bonded to the (V=O) also. Biological analysis for potential cytotoxic effects of 1 was performed using Human Cervix Adenocarcinoma (HeLa) cells, a human cervix adenocarcinoma-derived cell line. After incubation for 48 h, 1 causes 90 and 95% of HeLa cells death at 20 and 200 mol L-1, respectively.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Fis São Carlos, São Carlos, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim Araraquara, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1561-1571
dc.identifierhttp://dx.doi.org/10.1080/00958970802663555
dc.identifier.citationJournal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 62, n. 10, p. 1561-1571, 2009.
dc.identifier.doi10.1080/00958970802663555
dc.identifier.issn0095-8972
dc.identifier.urihttp://hdl.handle.net/11449/42117
dc.identifier.wosWOS:000265303500002
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Coordination Chemistry
dc.relation.ispartofjcr1.703
dc.relation.ispartofsjr0,371
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectVanadiumen
dc.subjectComplexen
dc.subjectCrystal structureen
dc.subjectGlycolateen
dc.subjectGlycolicen
dc.titleSynthesis, characterization, crystal structure, and biological studies of vanadium complexes with glycolic aciden
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd

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