The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats

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dc.contributor.authorAlmeida, FCG
dc.contributor.authorLemonica, I. P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:02Z
dc.date.available2014-05-20T13:49:02Z
dc.date.issued2000-11-01
dc.description.abstractExtracts of Coleus bal barbatus B. have been used in folk medicine to interrupt pregnancy. In order to evaluate if this plant interferes with embryo implantation or with the normal development of the concepts, pregnant Wistar rats were treated with increasing doses (220, 440 and 880 mg/kg per day) of a hydroalcoholic extract of C. barbatus. The rats received the extract by gavage from days 0 to 5 of pregnancy (preimplantation period) or 6 to 15 (organogenic period). Control groups received distilled water during the same periods: the animals were killed at term for the evaluation of maternal and fetal parameters. The results showed that the treatment with 880 mg/kg per day of the extract of C. barbatus before embryo implantation caused delayed fetal development and an anti-implantation effect, which justifies the popular use of this extract with abortive purposes. After embryo implantation delayed development associated with maternal toxicity was observed in the fetuses of the group which received 880 mg/kg per day. (C) 2000 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Lab Teratol Expt, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Lab Teratol Expt, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent53-60
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(00)00275-0
dc.identifier.citationJournal of Ethnopharmacology. Oxford: Elsevier B.V., v. 73, n. 1-2, p. 53-60, 2000.
dc.identifier.doi10.1016/S0378-8741(00)00275-0
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/11449/17462
dc.identifier.wosWOS:000089958900006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectColeus barbatuspt
dc.subjectembryotoxicitypt
dc.subjectanti-implantation effectpt
dc.subjectteratogenicitypt
dc.subjectmedicinal plantspt
dc.titleThe toxic effects of Coleus barbatus B. on the different periods of pregnancy in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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