The effect of oestrogen and alendronate therapies on postmenopausal bone loss around osseointegrated titanium implants

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dc.contributor.authorGiro, Gabriela [UNESP]
dc.contributor.authorCoelho, Paulo G.
dc.contributor.authorRodrigues Pereira, Rosa Maria
dc.contributor.authorJorgetti, Vanda
dc.contributor.authorMarcantonio, Elcio [UNESP]
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNYU
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2013-09-30T18:31:51Z
dc.date.accessioned2014-05-20T13:45:25Z
dc.date.available2013-09-30T18:31:51Z
dc.date.available2014-05-20T13:45:25Z
dc.date.issued2011-03-01
dc.description.abstractObjectivesThis study evaluated the influence of oestrogen deficiency and its therapies on bone tissue around osseointegrated implants.MethodsImplants were placed in 66 female rats tibiae. The animals were assigned into five groups: control (CTL), sham, ovariectomy (OVX), oestrogen (EST), and alendronate (ALE). While CTL was sacrificed 60 days after implant placement, other groups were subjected to ovariectomy or sham surgery according to group and euthanized after 90 days. Blood and urine samples were collected at sacrifice day for osteocalcin (OCN) and deoxypyridinoline (DPD) quantification. Densitometry of femur and lumbar vertebrae was performed in order to evaluate rats' skeletal impairment. Non-decalcified sections were referred to fluorescent and light microscopy for analyses of mineral apposition rate (MAR), eroded and osteoclastic surfaces, bone-to-implant contact (BIC), and bone area fraction occupancy (BAFO).ResultsResults from the OVX group showed significantly lower bone mineral density (BMD), BIC, BAFO, and MAR, while OCN, deoxipiridinoline, eroded surface and ostecoclastic surface were increased compared with the other groups of the study. ALE reduced OCN and DPD concentrations, MAR, osteoclastic and eroded surfaces, and no difference was in BIC and BAFO relative to SHAM. EST and CTL showed similar results to SHAM for measurements.ConclusionsOestrogen deficiency exerted a negative influence on bone tissue around implants, while oestrogen replacement therapy and alendronate were effective against its effects. Although alendronate therapy maintained the quantity of bone around implants, studies evaluating bone turnover kinetics are warranted.To cite this article:Giro G, Coelho PG, Pereira RMR, Jorgetti V, Marcantonio E Jr, Orrico SRP. The effect of oestrogen and alendronate therapies on postmenopausal bone loss around osseointegrated titanium implants.Clin. Oral Impl. Res. 22, 2011; 259-264.doi: 10.1111/j.1600-0501.2010.01989.x.en
dc.description.affiliationUnesp Univ Estadual Paulista, Dept Oral Diag & Surg, Araraquara Dent Sch, Araraquara, SP, Brazil
dc.description.affiliationNYU, Dept Biomat & Biomimet, New York, NY USA
dc.description.affiliationUniv São Paulo, Fac Med, Bone Metab Lab, Div Rheumatol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Bone Metab Lab, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnespUnesp Univ Estadual Paulista, Dept Oral Diag & Surg, Araraquara Dent Sch, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent259-264
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0501.2010.01989.x
dc.identifier.citationClinical Oral Implants Research. Malden: Wiley-blackwell, v. 22, n. 3, p. 259-264, 2011.
dc.identifier.doi10.1111/j.1600-0501.2010.01989.x
dc.identifier.issn0905-7161
dc.identifier.lattes7383391319292040
dc.identifier.urihttp://hdl.handle.net/11449/15977
dc.identifier.wosWOS:000286891100004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalendronateen
dc.subjectdental implantsen
dc.subjectoestrogen replacement therapyen
dc.subjectosteoporosisen
dc.subjectovariectomyen
dc.subjectratsen
dc.titleThe effect of oestrogen and alendronate therapies on postmenopausal bone loss around osseointegrated titanium implantsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes7383391319292040
unesp.author.orcid0000-0002-9660-4524[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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