Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes

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dc.contributor.authorCorrea, Fernanda O. B. [UNESP]
dc.contributor.authorGoncalves, Daniela [UNESP]
dc.contributor.authorFigueredo, Carlos M. S.
dc.contributor.authorBastos, Alliny S. [UNESP]
dc.contributor.authorGustafsson, Anders
dc.contributor.authorOrrico, Silvana Regina Perez [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionKarolinska Inst
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.date.accessioned2013-09-30T18:31:49Z
dc.date.accessioned2014-05-20T13:45:24Z
dc.date.available2013-09-30T18:31:49Z
dc.date.available2014-05-20T13:45:24Z
dc.date.issued2010-01-01
dc.description.abstractP>ObjectiveThe aim of this study was to investigate the effect of periodontal therapy on the circulating concentration of high-sensitivity capsule-reactive protein (hs-CRP), fibrinogen (FIB), interleukin (IL)-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) and on the metabolic control in type 2 diabetes mellitus (T2DM) patients.Material and MethodsTwenty-three T2DM patients with chronic periodontitis were enrolled in this study. Periodontal clinical parameters, namely visible plaque index, gingival bleeding index, bleeding on probing, probing depth and clinical attachment levels, were evaluated. Blood samples for plasma were collected and assessed for the levels of hs-CRP, FIB, IL-4, IL-6, IL-8, IL-10 and TNF-alpha. The glycated haemoglobin (HbA(1c)) and fasting plasma glucose were also measured. All parameters were evaluated before and 3 months after non-surgical periodontal therapy.ResultsAll clinical parameters were significantly improved 3 months after the periodontal therapy. A univariate comparison showed a tendency towards a decrease of the measured biomarkers, most pronounced for TNF-alpha and FIB, after therapy. Periodontal treatment also reduced HbA(1c) and hs-CRP levels, albeit not significantly.ConclusionsThe clinically successful non-surgical periodontal therapy tended to reduce systemic inflammation and the concentration of some circulating cytokines.en
dc.description.affiliationSão Paulo State Univ, Dept Diag & Surg, Sch Dent, Araraquara, SP, Brazil
dc.description.affiliationKarolinska Inst, Div Periodontol, Inst Odontol, Stockholm, Sweden
dc.description.affiliationUniversidade do Estado do Rio de Janeiro (UERJ), Dept Periodontol, Sch Dent, Rio de Janeiro, RJ, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Diag & Surg, Sch Dent, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 0948/06-3
dc.description.sponsorshipIdFAPESP: 04/08142-0
dc.format.extent53-58
dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2009.01498.x
dc.identifier.citationJournal of Clinical Periodontology. Malden: Wiley-blackwell Publishing, Inc, v. 37, n. 1, p. 53-58, 2010.
dc.identifier.doi10.1111/j.1600-051X.2009.01498.x
dc.identifier.issn0303-6979
dc.identifier.lattes7383391319292040
dc.identifier.urihttp://hdl.handle.net/11449/15967
dc.identifier.wosWOS:000272771700008
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofJournal of Clinical Periodontology
dc.relation.ispartofjcr4.046
dc.relation.ispartofsjr2,079
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiabetes mellitusen
dc.subjectfibrinogenen
dc.subjectglycaemic controlen
dc.subjectperiodontal diseaseen
dc.subjecttherapyen
dc.subjecttumour necrosis factor-alphaen
dc.titleEffect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.lattes7383391319292040
unesp.author.orcid0000-0003-0222-9231[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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