Origins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparum

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dc.contributor.authorHoffmann, Erika H. E.
dc.contributor.authorMalafronte, Rosely S.
dc.contributor.authorMoraes-Avila, Sandra L.
dc.contributor.authorOsakabe, Ana Lucia
dc.contributor.authorWunderlich, Gerhard
dc.contributor.authorDurham, Alan M.
dc.contributor.authorRibolla, Paulo Eduardo M.
dc.contributor.authordel Portillo, Hernando A.
dc.contributor.authorFerreira, Marcelo U.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHarvard Univ
dc.date.accessioned2014-05-20T15:21:48Z
dc.date.available2014-05-20T15:21:48Z
dc.date.issued2006-07-19
dc.description.abstractThe recent evolution of Plasmodium falciparum is at odds with the extensive polymorphism found in most genes coding for antigens. Here, we examined the patterns and putative mechanisms of sequence diversification in the merozoite surface protein-2 (MSP-2), a major malarial repetitive surface antigen. We compared the msp-2 gene sequences from closely related clones derived from sympatric parasite isolates from Brazilian Amazonia and used microsatellite typing to examine, in these same clones, the haplotype background of chromosome 2, where msp-2 is located. We found examples of msp-2 sequence rearrangements putatively created by nonreciprocal recombinational events, such as replication slippage and gene conversion, while maintaining the chromosome haplotype. We conclude that these nonreciprocal recombination events may represent a major source of antigenic diversity in MSP-2 in P falciparum populations with low rates of classical meiotic recombination. (c) 2006 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Parasitol, BR-05508900 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Trop Med São Paulo, BR-05403000 São Paulo, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Math & Stat, Dept Comp Sci, BR-05508900 São Paulo, SP, Brazil
dc.description.affiliationState Univ São Paulo, Inst Biosci Botucatu, Dept Parasitol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationHarvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 01238 USA
dc.description.affiliationUnespState Univ São Paulo, Inst Biosci Botucatu, Dept Parasitol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent224-230
dc.identifierhttp://dx.doi.org/10.1016/j.gene.2006.03.011
dc.identifier.citationGene. Amsterdam: Elsevier B.V., v. 376, n. 2, p. 224-230, 2006.
dc.identifier.doi10.1016/j.gene.2006.03.011
dc.identifier.issn0378-1119
dc.identifier.lattes3577149748456880
dc.identifier.orcid0000-0001-8735-6090
dc.identifier.urihttp://hdl.handle.net/11449/32911
dc.identifier.wosWOS:000239357700008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofGene
dc.relation.ispartofjcr2.498
dc.relation.ispartofsjr1,019
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmalariapt
dc.subjectMSP-2pt
dc.subjectrecombinationpt
dc.subjectantigenic diversitypt
dc.subjectreplication slippagept
dc.subjectgene conversionpt
dc.titleOrigins of sequence diversity in the malaria vaccine candidate merozoite surface protein-2 (MSP-2) in Amazonian isolates of Plasmodium falciparumen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3577149748456880[7]
unesp.author.orcid0000-0002-5293-9090[9]
unesp.author.orcid0000-0003-1724-0337[5]
unesp.author.orcid0000-0002-5278-3452[8]
unesp.author.orcid0000-0001-8735-6090[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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