The adrenergic regulation of the cardiovascular system in the South American rattlesnake, Crotalus durissus

Página do item simplificado
dc.contributor.authorGalli, Gina L. J.
dc.contributor.authorSkovgaard, Nini
dc.contributor.authorAbe, Augusto Shinya [UNESP]
dc.contributor.authorTaylor, Edwin W.
dc.contributor.authorWang, Tobias
dc.contributor.institutionAarhus University (AU)
dc.contributor.institutionUniv Birmingham
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:18:03Z
dc.date.available2014-05-20T13:18:03Z
dc.date.issued2007-11-01
dc.description.abstractThe present study investigates adrenergic regulation of the systemic and pulmonary circulations of the anaesthetised South American rattlesnake, Crotalus durissus. Haemodynamic measurements were made following bolus injections of adrenaline and adrenergic antagonists administered through a systemic arterial catheter. Adrenaline caused a marked systemic vasoconstriction that was abolished by phentolamine, indicating this response was mediated through alpha-adrenergic receptors. Injection of phentolamine gave rise to a pronounced vasodilatation (systemic conductance (G(sys)) more than doubled), while injection of propranolol caused a systemic vasoconstriction, pointing to a potent alpha-adrenergic, and a weaker beta-adrenergic tone in the systemic vasculature of Crotalus. Overall, the pulmonary vasculature was far less responsive to adrenergic stimulation than the systemic circulation. Adrenaline caused a small but non-significant pulmonary vasodilatation and there was tendency of reducing this dilatation after either phentolamine or propranolol. Injection of phentolamine increased pulmonary conductance (G(pul)), while injection of propranolol produced a small pulmonary constriction, indicating that alpha-adrenergic and beta-adrenergic receptors contribute to a basal regulation of the pulmonary vasculature. Our results suggest adrenergic regulation of the systemic vasculature, rather than the pultrionary, may be an important factor in the development of intracardiac shunts. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationAarhus Univ, Dept Biol Sci, DK-8000 Aarhus C, Denmark
dc.description.affiliationUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England
dc.description.affiliationUNESP, Dept Zool, Ctr Aquicultura, BR-13506970 Rio Claro, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Zool, Ctr Aquicultura, BR-13506970 Rio Claro, SP, Brazil
dc.format.extent510-520
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2007.06.420
dc.identifier.citationComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 148, n. 3, p. 510-520, 2007.
dc.identifier.doi10.1016/j.cbpa.2007.06.420
dc.identifier.issn1095-6433
dc.identifier.urihttp://hdl.handle.net/11449/4298
dc.identifier.wosWOS:000250656100004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectreptilept
dc.subjectsnakept
dc.subjectcardiovascular regulationpt
dc.subjectadrenalinept
dc.subjectadrenergic stimulationpt
dc.subjectpulmonary circulationpt
dc.subjectsystemic circulationpt
dc.titleThe adrenergic regulation of the cardiovascular system in the South American rattlesnake, Crotalus durissusen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8776757457144680[3]
unesp.author.orcid0000-0002-6765-8726[3]

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Jaboticabal - CAUNESP - Centro de Aquicultura da Unesp