Evaluation of different periods of estrogen replacement onset in the tibia of ovariectomized rats

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dc.contributor.authorSpalding, Marianne [UNESP]
dc.contributor.authorAmschlinger, Priscila Ferreira [UNESP]
dc.contributor.authorReis de Vasconcellos, Luana Marotta [UNESP]
dc.contributor.authorGouvea Lima, Gabriela de Morais [UNESP]
dc.contributor.authorKerbauy, Warley David [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-11-03T15:28:46Z
dc.date.available2015-11-03T15:28:46Z
dc.date.issued2014-10-01
dc.description.abstractBackground and aims Estrogen deficiency results in increased bone turnover and can lead to osteoporosis. Hormone replacement therapy (HRT) seems to be the most effective means of reducing bone loss and fractures. However, the effects of the period of HRT onset on bone tissue require further elucidation. This study aimed to evaluate the effects of different periods of HRT onset on the trabecular bone of ovariectomized rats.Methods Seventy-five ovariectomized Wistar rats were divided into five groups according to the onset of treatment. Each group was subdivided into experimental (E; n = 10) and control (C; n = 5), according to treatment with 17-beta-estradiol or vehicle alone (soybean oil), respectively, administered subcutaneously. The first group received treatment immediately post-surgery, while treatment in the remaining groups was initiated 1, 2, 3 and 4 weeks post-surgery. Euthanasia occurred at 9 weeks post-surgery. The left tibias were removed and prepared for histomorphometric analyses. The histomorphometric results were statistically analyzed by the Student's t test (p < 0.05).Results The percentage of trabecular bone was significantly greater in the first (p = 0.002) and second (p = 0.039) experimental subgroups compared with the control for the same period. In the experimental subgroups, the percentage of trabecular bone decreased according to the delay in HRT onset and was statistically significant (t = 3.367; p = 0.0023).Conclusion These findings indicate an increase in trabecular bone loss in tibia at 9 weeks post-ovariectomy. The period of HRT/E onset is important for preventing bone loss; however, despite its preventive effects, HRT/E does not restore lost bone.en
dc.description.affiliationUniv Estadual Paulista, Dept Biosci, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Oral Diagnosis Dent Sch, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Diag &Surg, Sch Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Community Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Pediat Clin, Sch Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biosci, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Oral Diagnosis Dent Sch, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Diag &Surg, Sch Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Community Dent, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Pediat Clin, Sch Dent, Sao Jose Dos Campos, SP, Brazil
dc.format.extent465-471
dc.identifierhttp://link.springer.com/article/10.1007%2Fs40520-014-0268-1
dc.identifier.citationAging Clinical And Experimental Research. New York: Springer, v. 26, n. 5, p. 465-471, 2014.
dc.identifier.doi10.1007/s40520-014-0268-1
dc.identifier.issn1594-0667
dc.identifier.lattes1374626424632581
dc.identifier.lattes6835876859385427
dc.identifier.lattes6967369119792151
dc.identifier.lattes1374626424632581
dc.identifier.urihttp://hdl.handle.net/11449/130036
dc.identifier.wosWOS:000346809100001
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAging Clinical And Experimental Research
dc.relation.ispartofjcr2.121
dc.relation.ispartofsjr0,670
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHormone replacement therapyen
dc.subjectEstrogenen
dc.subjectPostmenopausal bone lossen
dc.subjectOvariectomyen
dc.titleEvaluation of different periods of estrogen replacement onset in the tibia of ovariectomized ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1374626424632581
unesp.author.lattes6835876859385427
unesp.author.lattes6967369119792151
unesp.author.lattes1374626424632581
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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