Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

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dc.contributor.authorContessoto, Vinícius G. [UNESP]
dc.contributor.authorDudchenko, Olga
dc.contributor.authorAiden, Erez Lieberman
dc.contributor.authorWolynes, Peter G.
dc.contributor.authorOnuchic, José N.
dc.contributor.authorDi Pierro, Michele
dc.contributor.institutionRice University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionBaylor College of Medicine
dc.contributor.institutionNortheastern University
dc.date.accessioned2023-07-29T13:38:10Z
dc.date.available2023-07-29T13:38:10Z
dc.date.issued2023-12-01
dc.description.abstractWe use data-driven physical simulations to study the three-dimensional architecture of the Aedes aegypti genome. Hi-C maps exhibit both a broad diagonal and compartmentalization with telomeres and centromeres clustering together. Physical modeling reveals that these observations correspond to an ensemble of 3D chromosomal structures that are folded over and partially condensed. Clustering of the centromeres and telomeres near the nuclear lamina appears to be a necessary condition for the formation of the observed structures. Further analysis of the mechanical properties of the genome reveals that the chromosomes of Aedes aegypti, by virtue of their atypical structural organization, are highly sensitive to the deformation of the nuclei. This last finding provides a possible physical mechanism linking mechanical cues to gene regulation.en
dc.description.affiliationCenter for Theoretical Biological Physics Rice University
dc.description.affiliationInstituto de Biociências Letras e Ciências Exatas UNESP - Univ. Estadual Paulista Departamento de Física, SP
dc.description.affiliationThe Center for Genome Architecture Department of Molecular and Human Genetics Baylor College of Medicine
dc.description.affiliationDepartment of Physics & Astronomy Rice University
dc.description.affiliationDepartment of Chemistry Rice University
dc.description.affiliationDepartment of Biosciences Rice University
dc.description.affiliationDepartment of Physics Northeastern University
dc.description.affiliationCenter for Theoretical Biological Physics Northeastern University
dc.description.affiliationUnespInstituto de Biociências Letras e Ciências Exatas UNESP - Univ. Estadual Paulista Departamento de Física, SP
dc.description.sponsorshipWelch Foundation
dc.description.sponsorshipNational Science Foundation
dc.description.sponsorshipNational Institute of General Medical Sciences
dc.description.sponsorshipIdWelch Foundation: Grant C-1792
dc.description.sponsorshipIdNational Science Foundation: PHY-2210291
dc.description.sponsorshipIdWelch Foundation: Q-1866
dc.description.sponsorshipIdNational Institute of General Medical Sciences: R35GM146852
dc.identifierhttp://dx.doi.org/10.1038/s41467-023-35909-2
dc.identifier.citationNature Communications, v. 14, n. 1, 2023.
dc.identifier.doi10.1038/s41467-023-35909-2
dc.identifier.issn2041-1723
dc.identifier.scopus2-s2.0-85146545890
dc.identifier.urihttp://hdl.handle.net/11449/248229
dc.language.isoeng
dc.relation.ispartofNature Communications
dc.sourceScopus
dc.titleInterphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cuesen
dc.typeArtigo
unesp.author.orcid0000-0002-1891-9563[1]
unesp.author.orcid0000-0001-9163-9544[2]
unesp.author.orcid0000-0001-7975-9287[4]
unesp.author.orcid0000-0002-9448-0388[5]
unesp.author.orcid0000-0002-2889-2632[6]

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