Functional relationship between subfrnical organ cholinergic stimulation and nitrergic activation influencing cardiovascular and body fluid homeostasis

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dc.contributor.authorSaad, Wilson Abrao
dc.contributor.authorGuarda, Ismael Francisco Motta Siqueira
dc.contributor.authorCamargo, Luis Antonio de Arruda
dc.contributor.authordos Santos, Talmir Augusto Faria Brisola
dc.contributor.authorSaad, William Abrao
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Taubate
dc.contributor.institutionCentro Univ Araraquara
dc.contributor.institutionClin Hosp State São Paulo
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T13:45:44Z
dc.date.available2014-05-20T13:45:44Z
dc.date.issued2007-10-04
dc.description.abstractWe have studied the effects of L-NG-nitro arginine methyl esther (L-NAME), L-arginine (LAR), inhibitor and a donating nitric oxide agent on the alterations of salivary flow, water intake, arterial blood pressure (MAP) and heart rate (HR) induced by the injection pilocarpine into the subfornical organ (SFO). Rats (Holtzman 250-300 g) were anesthetized with 2, 2, 2-tribromoethanol (20 mg/100 kg b. wt.) and a stainless steel carmula were implanted into their SFO. The volume of injection was 0.2 mu l. The amount of saliva secretion was studied over a 5-min period. Pilocarpine (40 mu g), L-NAME (40 mu g) and LAR (30 mu g) were used in all experiments for the injection into the SFO. Pilocarpine (10, 20, 40, 80 and 160 mu g) injected into SFO elicited a concentration-dependent increase in salivary secretion. L-NAME injected prior to pilocarpine into the SFO increased salivary secretion and water intake due to the effect of pilocarpine. LAR injected prior to pilocarpine into the SFO attenuated the salivary secretion and water intake. Pilocarpine, injected into the SFO increased the MAP and decreased heart rate (HR). L-NAME injected prior to pilocarpine into the SFO potentiated the pressor effect of pilocarpine with a decrease in HR. LAR injected into the SFO prior to pilocarpine attenuated the increase in MAP with no changes in HR. The present study suggests that the SFO nitrergic cells interfere in the cholinergic pathways implicated in the control of salivary secretion, fluid and cardiovascular homeostasis. (c) 2007 Elsevier B.V All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUniv Taubate, Basic Inst Biosci, Taubate, SP, Brazil
dc.description.affiliationCentro Univ Araraquara, Dept Exact & Nat Sci, Araraquara, SP, Brazil
dc.description.affiliationClin Hosp State São Paulo, Dept Anesthesiol, São Paulo, Brazil
dc.description.affiliationClin Hosp State São Paulo, Dept Gastrol, São Paulo, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiol, BR-13560 Sao Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Physiol & Pathol, Sch Dent, BR-14801903 Araraquara, SP, Brazil
dc.format.extent28-33
dc.identifierhttp://dx.doi.org/10.1016/j.regpep.2007.01.013
dc.identifier.citationRegulatory Peptides. Amsterdam: Elsevier B.V., v. 143, n. 1-3, p. 28-33, 2007.
dc.identifier.doi10.1016/j.regpep.2007.01.013
dc.identifier.issn0167-0115
dc.identifier.urihttp://hdl.handle.net/11449/16118
dc.identifier.wosWOS:000249459100003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRegulatory Peptides
dc.relation.ispartofsjr0,512
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpilocarpinept
dc.subjectsubfornical organpt
dc.subjectnitric oxidept
dc.subjectsalivapt
dc.subjectfluid and cardiovascular balancept
dc.titleFunctional relationship between subfrnical organ cholinergic stimulation and nitrergic activation influencing cardiovascular and body fluid homeostasisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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