The effect of Ketoconazole on experimental paracoccidioidomycosis in the Syrian hamster: immunological and histopathological study

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dc.contributor.authorMota, N. G S [UNESP]
dc.contributor.authorViero, Rosa Marlene [UNESP]
dc.contributor.authorRezkallah-Iwasso, M. T. [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorSoares, Ângela Maria Victoriano de Campos [UNESP]
dc.contributor.authorMontenegro, M. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-26T22:48:30Z
dc.date.available2014-05-26T22:48:30Z
dc.date.issued1984-12-01
dc.description.abstractThe effect of Ketoconazole (KTZ) on the hamster experimental intratesticular paracoccidioidomycosis was studied employing different treatment schedules. KTZ long course treatment beginning at an early stage of the infection was effective in preventing fungal proliferation, dissemination to lymph nodes, spleen and kidneys, and in maintaining low levels of humoral and cellular specific immune responses. KTZ short course treatment starting at an advanced stage of disease resulted in a more severe histopathological picture without significant changes in the immunological profile. The drug prolonged the life span of hamsters infected with Paracoccidioides brasiliensis, but did not prevent mortality. Toxic necrosis of the bone marrow occurred in normal animals receiving 120 mg/kg/day of KTZ but with lower doses no morphologic alterations were observed in heart, lungs, kidneys, adrenals, spleen, liver, intestine or bone marrow. © 1984 Dr W. Junk Publishers.en
dc.description.affiliationDepartment of Microbiology and Immunology IBBMA, UNESP, Rbiõ Junior, Botucatu, São Paulo, 18610
dc.description.affiliationDepartment of Pathology UNESP, Botucatu, São Paulo
dc.description.affiliationUnespDepartment of Microbiology and Immunology IBBMA, UNESP, Rbiõ Junior, Botucatu, São Paulo, 18610
dc.description.affiliationUnespDepartment of Pathology UNESP, Botucatu, São Paulo
dc.format.extent141-148
dc.identifierhttp://dx.doi.org/10.1007/BF00436445
dc.identifier.citationMycopathologia, v. 88, n. 2-3, p. 141-148, 1984.
dc.identifier.doi10.1007/BF00436445
dc.identifier.issn0301-486X
dc.identifier.issn1573-0832
dc.identifier.lattes1453564171333848
dc.identifier.lattes6486557387397806
dc.identifier.scopus2-s2.0-0021689995
dc.identifier.urihttp://hdl.handle.net/11449/63674
dc.language.isoeng
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.relation.ispartofsjr0,597
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectketoconazole
dc.subjectphytohemagglutinin
dc.subjectanimal experiment
dc.subjectdose response
dc.subjectdrug efficacy
dc.subjectdrug response
dc.subjectdrug therapy
dc.subjectdrug toxicity
dc.subjectexperimental infection
dc.subjecthistology
dc.subjectintoxication
dc.subjectmethodology
dc.subjectmycosis
dc.subjectnonhuman
dc.subjectoral drug administration
dc.subjectsouth american blastomycosis
dc.subjecttherapy
dc.subjectAnimals
dc.subjectCell Migration Inhibition
dc.subjectCricetinae
dc.subjectImmunodiffusion
dc.subjectKetoconazole
dc.subjectMacrophages
dc.subjectMale
dc.subjectMesocricetus
dc.subjectParacoccidioidomycosis
dc.subjectAnimalia
dc.subjectMesocricetus auratus
dc.subjectParacoccidioides brasiliensis
dc.titleThe effect of Ketoconazole on experimental paracoccidioidomycosis in the Syrian hamster: immunological and histopathological studyen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.advisor.lattes6486557387397806
unesp.author.lattes1453564171333848
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB
Artigos - Patologia - FMB