Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves

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dc.contributor.authorBernal, Laura Priscila Toledo
dc.contributor.authorLeitão, Maicon Matos
dc.contributor.authorRadai, Joyce Alencar Santos
dc.contributor.authorCardoso, Claudia Andrea Lima [UNESP]
dc.contributor.authorLencina, Joyce dos Santos
dc.contributor.authorFraga, Thiago Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.authorSilva-Filho, Saulo Euclides
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversity Center Unigran (UNIGRAN)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2023-07-29T15:42:24Z
dc.date.available2023-07-29T15:42:24Z
dc.date.issued2023-03-01
dc.description.abstractEthnopharmacological relevance: The infusion of Serjania erecta Radlk (Sapindaceae) (popular name “cipó-cinco-folhas”) leaves is used in popular medicine to treat back pain. The anti-inflammatory, anti-hyperalgesic and anti-nociceptive properties of the ethanolic extract from S. erecta leaves (EESE) has not been yet completely clarified. Aim of the study: The present study investigated the anti-hyperalgesic, anti-nociceptive and anti-inflammatory properties of EESE in experimental models in mice. Material and methods: EESE was fractionated by chromatographic techniques and the compound was identified by nuclear magnetic resonance (NMR), infrared (IR) spectrum, ultraviolet (UV) methods. Mice received a single dose of EESE by oral route (30, 100, and 300 mg/kg, p.o.) and were submitted to nociception induced by formalin, pleurisy induced by carrageenan and peritonitis induced by zymosan models. Mice also received EESE (30 and 100 mg/kg, p.o.) for 22 days in Complete Freund Adjuvant (CFA) model and another group received EESE for 7 days (30 and 100 mg/kg, p.o.) in pleurisy induced by Bacillus Calmette-Guerin (BCG). The cytotoxicity (MTT), phagocytic and chemotactic inhibitory activities of EESE were performed in in vitro assays. Results: The fractionation of EESE led to the identification of kaempferol-3-O-α-L-rhamnopyranoside. The oral administration of all doses of EESE decreased the nociceptive response induced by formalin. EESE significantly inhibited leukocyte migration in carrageenan-induced pleurisy and zymosan peritonitis models. The daily administration of EESE during for 7 days inhibited the leukocyte migration and the mycobacteria growth of pleural material obtained from animals which received BCG. EESE significantly reduced edema, cold allodynia and mechanical hyperalgesia responses induced by CFA. EESE did not induce cytotoxicity, and also decreased the leukocyte phagocytic activity, as well as, neutrophil chemotaxis. Conclusions: EESE showed analgesic and anti-inflammatory properties in acute and persistent experimental models in mice. EESE also reduced in vitro leukocyte chemotaxis and phagocytic activity without inducing cytotoxicity. The continuous oral treatment with EESE was effective against hyperalgesia and inflammation and these results could explain the popular use of S. erecta as an analgesic natural agent.en
dc.description.affiliationFaculty of Health Sciences Federal University of Grande Dourados, MS
dc.description.affiliationSchool of Health Sciences University Center Unigran (UNIGRAN), MS
dc.description.affiliationCenter of Studies in Natural Resources State University of Mato Grosso do Sul (UNESP)
dc.description.affiliationPharmaceutical Sciences Food and Nutrition College Federal University of Mato Grosso do Sul (UFMS)
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu, São Paulo State
dc.description.affiliationUnespCenter of Studies in Natural Resources State University of Mato Grosso do Sul (UNESP)
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP) - Botucatu, São Paulo State
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2022.116019
dc.identifier.citationJournal of Ethnopharmacology, v. 303.
dc.identifier.doi10.1016/j.jep.2022.116019
dc.identifier.issn1872-7573
dc.identifier.issn0378-8741
dc.identifier.scopus2-s2.0-85144031083
dc.identifier.urihttp://hdl.handle.net/11449/249478
dc.language.isoeng
dc.relation.ispartofJournal of Ethnopharmacology
dc.sourceScopus
dc.subjectBacillus calmette-guerin (BCG)
dc.subjectComplete freund adjuvant (CFA)
dc.subjectMice
dc.subjectPain
dc.subjectSapindaceae
dc.subjectSerjania erecta
dc.titleAnalgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leavesen
dc.typeArtigo
unesp.author.orcid0000-0002-5275-0394[1]
unesp.author.orcid0000-0002-4907-0056[4]
unesp.author.orcid0000-0002-9676-7622[8]
unesp.author.orcid0000-0002-8998-9219[9]

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