A deterministic simulation study of embryo marker-assisted selection for age at first calving in Nellore (Bos indicus) beef cattle

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dc.contributor.authorRosa, Artur J.M.
dc.contributor.authorBijma, Piter
dc.contributor.authorOliveira, Henrique Nunes de [UNESP]
dc.contributor.authorLôbo, Raysildo B.
dc.contributor.authorvan Arendonk, Johan A.M.
dc.contributor.institutionUniversity of Palermo
dc.contributor.institutionWageningen University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:17:30Z
dc.date.available2014-05-20T15:17:30Z
dc.date.issued2007-01-01
dc.description.abstractWe used deterministic simulation of four alternative multiple ovulation and embryo manipulation (MOET) closed nucleus schemes to investigate the benefits of using marker-assisted selection (MAS) of Nellore (Bos indicus) beef cattle embryos prior to transplantation to reduce the age at first calving (AFC). We found that MAS resulted in increased genetic gain as compared to selection without AFC quantitative trait loci (AFC-QTL) information. With single-stage selection the genetic response (GR) increased as follows: GR = 0.68% when the AFC-QTL explained 0.02 of the AFC additive genetic variance (sigma2A); GR = 1.76% for AFC-QTL explaining 0.05 sigma2A; GR = 3.7% for AFC-QTL explaining 0.1 sigma2A; and GR = 55.76% for AFC-QTL explaining 0.95 sigma2A. At the same total selected proportion, two-stage selection resulted in less genetic gain than single stage MAS at two-years of age. A single stage selection responses of > 95% occurred with pre-selected proportions of 0.4 (0.1 sigma2A explained by AFC-QTL), 0.2 (0.3 sigma2A explained by AFC-QTL) and 0.1 (0.5 sigma2A explained by AFC-QTL), indicating that the combined use of MAS and pre-selection can substantially reduce the cost of keeping recipient heifers in MOET breeding schemes. When the number of recipients was kept constant, the benefit of increasing embryo production was greater for the QTL explaining a higher proportion of the additive genetic variance. However this advantage had a diminishing return especially for QTL explaining a small proportion of the additive genetic variance. Thus, marker assisted selection of embryos can be used to achieve increased genetic gain or a similar genetic response at reduced expense by decreasing the number of recipient cows and number of offspring raised to two-years of age.en
dc.description.affiliationUniversity of Palermo Department of Entomology, Phytopathology, Microbiology, Agriculture and Animal Science
dc.description.affiliationWageningen University Animal Breeding and Genetics Group
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Medicina Veterinária Departamento de Melhoramento e Nutrição Animal
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Departamento de Genética
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Medicina Veterinária Departamento de Melhoramento e Nutrição Animal
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent552-559
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572007000400008
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 3, p. 552-559, 2007.
dc.identifier.doi10.1590/S1415-47572007000400008
dc.identifier.fileS1415-47572007000400008.pdf
dc.identifier.issn1415-4757
dc.identifier.lattes5593441035110683
dc.identifier.scieloS1415-47572007000400008
dc.identifier.urihttp://hdl.handle.net/11449/30495
dc.language.isoeng
dc.publisherSociedade Brasileira de Genética
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.ispartofjcr1.493
dc.relation.ispartofsjr0,638
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectage at first calvingen
dc.subjectBeef cattleen
dc.subjectMarker assisted selectionen
dc.subjectpre-selectionen
dc.subjectquantitative trait locien
dc.titleA deterministic simulation study of embryo marker-assisted selection for age at first calving in Nellore (Bos indicus) beef cattleen
dc.typeArtigo
unesp.author.lattes5593441035110683
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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