Candida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolates

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dc.contributor.authorBruder-nascimento, Ariane [UNESP]
dc.contributor.authorCamargo, Carlos Henrique [UNESP]
dc.contributor.authorMondelli, Alessandro Lia [UNESP]
dc.contributor.authorSugizaki, Maria Fátima [UNESP]
dc.contributor.authorSadatsune, Terue [UNESP]
dc.contributor.authorBagagli, Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-26T19:19:16Z
dc.date.available2015-08-26T19:19:16Z
dc.date.issued2014-12-01
dc.description.abstractOver the last decades, there have been important changes in the epidemiology of Candida infections. In recent years, Candida species have emerged as important causes of invasive infections mainly among immunocompromised patients. This study analyzed Candida spp. isolates and compared the frequency and biofilm production of different species among the different sources of isolation: blood, urine, vulvovaginal secretions and peritoneal dialysis fluid. Biofilm production was quantified in 327 Candida isolates obtained from patients attended at a Brazilian tertiary public hospital (Botucatu, Sao Paulo). C. albicans ALS3 gene polymorphism was also evaluated by determining the number of repeated motifs in the central domain. Of the 198 total biofilm-positive isolates, 72 and 126 were considered as low and high biofilm producers, respectively. Biofilm production by C. albicans was significantly lower than that by non-albicans isolates and was most frequently observed in C. tropicalis. Biofilm production was more frequent among bloodstream isolates than other clinical sources,in urine, the isolates displayed a peculiar distribution by presenting two distinct peaks, one containing biofilm-negative isolates and the other containing isolates with intense biofilm production. The numbers of tandem-repeat copies per allele were not associated with biofilm production, suggesting the evolvement of other genetic determinants.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências de Botucatu
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2007/01946-4
dc.description.sponsorshipIdFAPESP: 2008/10835-4
dc.description.sponsorshipIdFAPESP: 2008/09231-7
dc.format.extent1371-1377
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400030&lng=en&nrm=iso&tlng=en
dc.identifier.citationBrazilian Journal of Microbiology, v. 45, n. 4, p. 1371-1377, 2014.
dc.identifier.doi10.1590/S1517-83822014000400030
dc.identifier.fileS1517-83822014000400030.pdf
dc.identifier.issn1517-8382
dc.identifier.lattes3320327570429539
dc.identifier.orcid0000-0002-8003-4109
dc.identifier.scieloS1517-83822014000400030
dc.identifier.urihttp://hdl.handle.net/11449/127347
dc.language.isoeng
dc.publisherSociedade Brasileira de Microbiologia
dc.relation.ispartofBrazilian Journal of Microbiology
dc.relation.ispartofjcr1.810
dc.relation.ispartofsjr0,630
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectCandida spp.en
dc.subjectBiofilmen
dc.subjectALS3 geneen
dc.titleCandida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolatesen
dc.typeArtigo
unesp.author.lattes3320327570429539[6]
unesp.author.lattes7697507273984482[3]
unesp.author.orcid0000-0002-4401-5656[3]
unesp.author.orcid0000-0002-8003-4109[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB