Genome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus)

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dc.contributor.authorSantana, M. H. A.
dc.contributor.authorUtsunomiya, Y. T. [UNESP]
dc.contributor.authorNeves, H. H. R. [UNESP]
dc.contributor.authorGomes, R. C.
dc.contributor.authorGarcia, J. F. [UNESP]
dc.contributor.authorFukumasu, H.
dc.contributor.authorSilva, S. L.
dc.contributor.authorLeme, P. R.
dc.contributor.authorCoutinho, L. L.
dc.contributor.authorEler, J. P.
dc.contributor.authorFerraz, J. B. S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2014-12-03T13:08:56Z
dc.date.available2014-12-03T13:08:56Z
dc.date.issued2014-06-01
dc.description.abstractThe genome-wide association study (GWAS) results are presented for average daily gain (ADG) in Nellore cattle. Phenotype of 720 male Bos indicus animals with information of ADG in feedlots and 354147 single-nucleotide polymorphisms (SNPs) obtained from a database added by information from Illumina Bovine HD (777962 SNPs) and Illumina BovineSNP50 (54609) by imputation were used. After quality control and imputation, 290620 SNPs remained in the association analysis, using R package Genome-wide Rapid Association using Mixed Model and Regression method GRAMMAR-Gamma. A genomic region with six significant SNPs, at Bonferroni-corrected significance, was found on chromosome 3. The most significant SNP (rs42518459, BTA3: 85849977, p=9.49x10(-8)) explained 5.62% of the phenotypic variance and had the allele substitution effect of -0.269kg/day. Important genes such as PDE4B, LEPR, CYP2J2 and FGGY are located near this region, which is overlapped by 12 quantitative trait locus (QTLs) described for several production traits. Other regions with markers with suggestive effects were identified in BTA6 and BTA10. This study showed regions with major effects on ADG in Bos indicus in feedlots. This information may be useful to increase the efficiency of selecting this trait and to understand the physiological processes involved in its regulation.en
dc.description.affiliationUniv Sao Paulo, Fac Zootecnia & Engn Alimentos, USP, Pirassununga, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciencias Agr & Vet, Jaboticabal, Brazil
dc.description.affiliationCNPGC EMBRAPA, Empresa Brasileira Pesquisa Agr, Campo Grande, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Med Vet Aracatuba, Aracatuba, Brazil
dc.description.affiliationUniv Sao Paulo, USP, Escola Super Agr Luiz de Queiroz, Piracicaba, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciencias Agr & Vet, Jaboticabal, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Med Vet Aracatuba, Aracatuba, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 11/16643-2
dc.description.sponsorshipIdFAPESP: 12/02039-9
dc.description.sponsorshipIdFAPESP: 12/03551-5
dc.format.extent210-216
dc.identifierhttp://dx.doi.org/10.1111/jbg.12084
dc.identifier.citationJournal Of Animal Breeding And Genetics. Hoboken: Wiley-blackwell, v. 131, n. 3, p. 210-216, 2014.
dc.identifier.doi10.1111/jbg.12084
dc.identifier.issn0931-2668
dc.identifier.urihttp://hdl.handle.net/11449/111729
dc.identifier.wosWOS:000335958000007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Animal Breeding and Genetics
dc.relation.ispartofjcr1.941
dc.relation.ispartofsjr0,804
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBos indicusen
dc.subjectgenomicen
dc.subjectgrowthen
dc.subjectgenome-wide association studyen
dc.subjectweight gainen
dc.subjectzebuen
dc.titleGenome-wide association study for feedlot average daily gain in Nellore cattle (Bos indicus)en
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.orcid0000-0002-7266-8881[9]
unesp.author.orcid0000-0002-3265-5090[6]
unesp.author.orcid0000-0002-9144-7697[1]
unesp.author.orcid0000-0002-6526-8337[2]
unesp.author.orcid0000-0002-0849-9948[7]

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