Human breast tumor slices as an alternative approach to cell lines to individualize research for each patient

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dc.contributor.authorConde, Sandro Jose [UNESP]
dc.contributor.authorMelo Luvizotto, Renata de Azevedo [UNESP]
dc.contributor.authorde Sibio, Maria Teresa [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:19Z
dc.date.available2014-05-20T13:33:19Z
dc.date.issued2012-07-01
dc.description.abstractThere are several breast cancer experimental models including cell lines, which are commonly used due to ease of handling and storage. However, the continued propagation of cell lines and distribution among laboratories results in genetic drift and distancing from the in-vivo model. Primary organ culture of breast cancer slices may produce biological responses with high standard deviation for different samples, reflecting the heterogeneity of different tumors. Thus, the organ culture model system offers a new perspective to the results obtained in the cell lines and offers an alternative for studies that seek to individualize treatment for each patient, an increasingly prominent concern in current cancer therapy. European Journal of Cancer Prevention 21:333-335 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en
dc.description.affiliationUNESP, Dept Clin Med, Div Endocrinol & Metab, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Clin Med, Div Endocrinol & Metab, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 05/55459-1
dc.format.extent333-335
dc.identifierhttp://dx.doi.org/10.1097/CEJ.0b013e32834dbc42
dc.identifier.citationEuropean Journal of Cancer Prevention. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 4, p. 333-335, 2012.
dc.identifier.doi10.1097/CEJ.0b013e32834dbc42
dc.identifier.issn0959-8278
dc.identifier.urihttp://hdl.handle.net/11449/11401
dc.identifier.wosWOS:000304528400004
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofEuropean Journal of Cancer Prevention
dc.relation.ispartofjcr2.886
dc.relation.ispartofsjr1,021
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subject17 beta-estradiolen
dc.subjectbreast neoplasmsen
dc.subjectcell culture techniquesen
dc.subjectcell lineen
dc.subjectprimary tumor slices cultureen
dc.subjecttriiodothyronineen
dc.subjecttumoren
dc.titleHuman breast tumor slices as an alternative approach to cell lines to individualize research for each patienten
dc.typeArtigo
dcterms.licensehttp://edmgr.ovid.com/spine/accounts/copyrightTransfer.pdf
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes7607038776901890[4]
unesp.author.orcid0000-0002-7354-9518[4]
unesp.author.orcid0000-0003-1876-5418[1]
unesp.author.orcid0000-0002-4014-0660[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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