Thermal and Structural Behavior of Dioctadecyldimethylammonium Bromide Dispersions Studied by Differential Scanning Calorimetry and X-Ray Scattering

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dc.contributor.authorFeitosa, Eloi
dc.contributor.authorAdati, Renata Danielle [UNESP]
dc.contributor.authorHansson, Per
dc.contributor.authorMalmsten, Martin
dc.contributor.institutionUppsala Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:02:43Z
dc.date.available2014-05-20T14:02:43Z
dc.date.issued2012-09-06
dc.description.abstractDioctadecyldimethylammonium bromide (DODAB) is a double chain cationic lipid, which assembles as bilayer structures in aqueous solution. The precise structures formed depend on, e.g., lipid concentration and temperature. We here combine differential scanning calorimetry (DSC) and X-ray scattering (SAXS and WAXS) to investigate the thermal and structural behavior of up to 120 mM DODAB in water within the temperature range 1-70 degrees C. Below 1 mM, this system is dominated by unilamellar vesicles (ULVs). Between 1 and 65 mM, ULVs and multilamellar structures (MLSs) co-exist, while above 65 mM, the MLSs are the preferred structure. Depending on temperature, DSC and X-ray data show that the vesicles can be either in the subgel (SG), gel, or liquid crystalline (LC) state, while the MLSs (with lattice distance d = 36.7 angstrom) consist of interdigitated lamellae in the SG state, and ULVs in the LC state (no Bragg peak). Critical temperatures related to the thermal transitions of these bilayer structures obtained in the heating and cooling modes are reported, together with the corresponding transition enthalpies.en
dc.description.affiliationUppsala Univ, Dept Pharm, Uppsala, Sweden
dc.description.affiliationSão Paulo State Univ, Dept Phys, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Phys, Sao Jose do Rio Preto, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipSwedish Research Council
dc.description.sponsorshipIdFAPESP: 11/00796-4
dc.description.sponsorshipIdFAPESP: 11/07414-0
dc.description.sponsorshipIdSwedish Research Council: 2009-3009
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0044702
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 7, n. 9, p. 9, 2012.
dc.identifier.doi10.1371/journal.pone.0044702
dc.identifier.fileWOS000308458400106.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11449/22105
dc.identifier.wosWOS:000308458400106
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPLOS ONE
dc.relation.ispartofjcr2.766
dc.relation.ispartofsjr1,164
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleThermal and Structural Behavior of Dioctadecyldimethylammonium Bromide Dispersions Studied by Differential Scanning Calorimetry and X-Ray Scatteringen
dc.typeArtigo
dcterms.licensehttp://www.plos.org/about/open-access/license/
dcterms.rightsHolderPublic Library Science
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Física - IBILCE