Validation of ACB in vitro and in vivo as a biomagnetic method for measuring stomach contraction

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dc.contributor.authorAmerico, Madileine Francely [UNESP]
dc.contributor.authorMarques, Rozemeire Garcia [UNESP]
dc.contributor.authorZandona, E. A. [UNESP]
dc.contributor.authorAndreis, Uilian de [UNESP]
dc.contributor.authorStelzer, Marcelo [UNESP]
dc.contributor.authorCora, Luciana Aparecida
dc.contributor.authorOliveira, Ricardo Brandt de
dc.contributor.authorMiranda, José Ricardo de Arruda [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Ciências da Saúde de Alagoas (UNCISAL)
dc.date.accessioned2014-05-20T13:49:36Z
dc.date.available2014-05-20T13:49:36Z
dc.date.issued2010-12-01
dc.description.abstractBackground The aim of this study was to validate a biomagnetic method (alternate current biosusceptometry, ACB) for monitoring gastric wall contractions in rats. Methods In vitro data were obtained to establish the relationship between ACB and the strain-gauge (SG) signal amplitude. In vivo experiments were performed in pentobarbital-anesthetized rats with SG and magnetic markers previously implanted under the gastric serosa or after ingestion of magnetic material. Gastric motility was quantified from the tracing amplitudes and frequency profiles obtained by Fast Fourier Transform. Key Results The correlation between in vitro signal amplitudes was strong (R = 0.989). The temporal cross-correlation coefficient between the ACB and SG signal amplitude was higher (P < 0.0001) in the postprandial (88.3 +/- 9.1 V) than in the fasting state (31.0 +/- 16.9 V). Irregular signal profiles, low contraction amplitudes, and smaller signal-to-noise ratios explained the poor correlation between techniques for fasting-state recordings. When a magnetic material was ingested, there was also strong correlation in the frequency and signal amplitude and a small phase-difference between the techniques. The contraction frequencies using ACB were 0.068 +/- 0.007 Hz (postprandial) and 0.058 +/- 0.007 Hz (fasting) (P < 0.002) and those using SG were 0.066 +/- 0.006 Hz (postprandial) and 0.059 +/- 0.008 Hz (fasting) (P < 0.005). Conclusions & Inferences In summary, ACB is reliable for monitoring gastric wall contractions using both implanted and ingested magnetic materials, and may serve as an accurate and sensitive technique for gastrointestinal motility studies.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Fis & Biofis, Inst Biociencias, BR-18618000 São Paulo, Brazil
dc.description.affiliationUFMT Univ Mato Grosso, Inst Ciencias Biol & Saude, Barra do Garcas, Mato Grosso, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Med, Dept Cirurgia & Ortopedia, BR-18618000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Clin Med, São Paulo, Brazil
dc.description.affiliationUNCISAL Alagoas State Univ Hlth Sci, Maceio, Alagoas, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Fis & Biofis, Inst Biociencias, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Med, Dept Cirurgia & Ortopedia, BR-18618000 São Paulo, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1340-1374
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2982.2010.01582.x
dc.identifier.citationNeurogastroenterology and Motility. Malden: Wiley-blackwell Publishing, Inc, v. 22, n. 12, p. 1340-1374, 2010.
dc.identifier.doi10.1111/j.1365-2982.2010.01582.x
dc.identifier.issn1350-1925
dc.identifier.lattes5083740415911673
dc.identifier.orcid0000-0002-5928-5608
dc.identifier.urihttp://hdl.handle.net/11449/17687
dc.identifier.wosWOS:000283988500015
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofNeurogastroenterology and Motility
dc.relation.ispartofjcr3.842
dc.relation.ispartofsjr2,095
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectDigestive physiologyen
dc.subjectFooden
dc.subjectGastrointestinal motilityen
dc.subjectInvestigative techniquesen
dc.subjectRatsen
dc.subjectTransducersen
dc.titleValidation of ACB in vitro and in vivo as a biomagnetic method for measuring stomach contractionen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.lattes5083740415911673[2]
unesp.author.orcid0000-0001-8242-3653[6]
unesp.author.orcid0000-0002-8306-8056[8]
unesp.author.orcid0000-0002-5928-5608[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Cirurgia e Ortopedia - FMB