Effect of the Single or Combined Administration of Cocaine and Testosterone on Cardiovascular Function and Baroreflex Activity in Unanesthetized Rats

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dc.contributor.authorEngi, Sheila A. [UNESP]
dc.contributor.authorCruz, Fabio C. [UNESP]
dc.contributor.authorLeao, Rodrigo M. [UNESP]
dc.contributor.authorCorrea, Fernando M.
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:25:32Z
dc.date.available2014-05-20T13:25:32Z
dc.date.issued2012-03-01
dc.description.abstractAbuse of cocaine and androgenic-anabolic steroids has become a serious public health problem. Despite reports of an increase in the incidence of simultaneous illicit use of these substances, potential toxic interactions between cocaine and androgenic-anabolic steroids in the cardiovascular system are unknown. In the present study, we investigated the effect of single or combined administration of testosterone and cocaine for 1 or 10 consecutive days on basal cardiovascular parameters, baroreflex activity, and hemodynamic responses to vasoactive agents in unanesthetized rats. Ten-day combined administration of testosterone and cocaine increased baseline arterial pressure. Changes in arterial pressure were associated with altered baroreflex activity and impairment of both hypotensive response to intravenous sodium nitroprusside and pressor effect of intravenous phenylephrine. Chronic single administration of either testosterone or cocaine did not affect baseline arterial pressure. However, testosterone-treated animals presented rest bradycardia, cardiac hypertrophy, alterations in baroreflex activity, and enhanced response to sodium nitroprusside. Repeated administration of cocaine affected baroreflex activity and impaired vascular responsiveness to both sodium nitroprusside and phenylephrine. One-day single or combined administration of the drugs did not affect any parameter investigated. In conclusion, the present results suggest a potential interaction between toxic effects of cocaine and testosterone on the cardiovascular activity. Changes in baseline arterial pressure after combined administration of these 2 drugs may result from alterations in baroreflex activity and impairment of vascular responsiveness to vasoactive agents.en
dc.description.affiliationSão Paulo State Univ, UNESP, Pharmacol Lab, Dept Nat Act Principles & Toxicol,Sch Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationJoint UFSCar UNESP Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.affiliationJoint UFSCar UNESP Grad Program Physiol Sci, São Carlos, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Pharmacol Lab, Dept Nat Act Principles & Toxicol,Sch Pharmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespJoint UFSCar UNESP Grad Program Physiol Sci, Araraquara, SP, Brazil
dc.description.affiliationUnespJoint UFSCar UNESP Grad Program Physiol Sci, São Carlos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 10/16192-8
dc.description.sponsorshipIdCNPq: 474177/2010-6
dc.format.extent231-240
dc.identifierhttp://dx.doi.org/10.1097/FJC.0b013e31823cc58b
dc.identifier.citationJournal of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 59, n. 3, p. 231-240, 2012.
dc.identifier.doi10.1097/FJC.0b013e31823cc58b
dc.identifier.issn0160-2446
dc.identifier.lattes2514762545280942
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.urihttp://hdl.handle.net/11449/8096
dc.identifier.wosWOS:000301285800004
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Cardiovascular Pharmacology
dc.relation.ispartofjcr2.227
dc.relation.ispartofsjr0,917
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectabuseen
dc.subjectanabolic steroidsen
dc.subjectcocaineen
dc.subjectcardiovascularen
dc.subjecthypertensionen
dc.subjecthypertrophyen
dc.subjectvascular reactivityen
dc.titleEffect of the Single or Combined Administration of Cocaine and Testosterone on Cardiovascular Function and Baroreflex Activity in Unanesthetized Ratsen
dc.typeArtigo
dcterms.licensehttp://journals.lww.com/_layouts/oaks.journals/nih.aspx
dcterms.rightsHolderLippincott Williams & Wilkins
unesp.author.lattes1117432571971568[6]
unesp.author.lattes2514762545280942[5]
unesp.author.orcid0000-0002-1942-858X[6]
unesp.author.orcid0000-0002-1378-6327[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR
Artigos - Fisiologia e Patologia - FOAR