Immunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.

Página do item simplificado
dc.contributor.authorDejani, Naiara N.
dc.contributor.authorSouza, Lais C.
dc.contributor.authorOliveira, Sandra R. P.
dc.contributor.authorNeris, Debora M.
dc.contributor.authorRodolpho, Joice M. A.
dc.contributor.authorCorreia, Ricardo O.
dc.contributor.authorRodrigues, Vanderlei
dc.contributor.authorSacramento, Luis V. S. [UNESP]
dc.contributor.authorFaccioli, Lucia H.
dc.contributor.authorAfonso, Ana
dc.contributor.authorAnibal, Fernanda F.
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Nova Lisboa
dc.date.accessioned2014-12-03T13:11:44Z
dc.date.available2014-12-03T13:11:44Z
dc.date.issued2014-08-01
dc.description.abstractSchistosomiasis is a chronic disease caused by an intravascular trematode of the genus Schistosoma. Praziquantel is the drug used for treatment of schistosomiasis; nevertheless failure of treatment has been reported. Consequently, the identification of new effective schistosomicidal compounds is essential to ensure the effective control of schistosomiasis in the future. In this work we investigated the immunomodulatory and antiparasitic effects of the crude leaves extract of Mentha x piperita L. (peppermint) on murine Schistosomiasis mansoni. Female Balb/c mice were infected each with 50 S. mansoni cercariae and divided into three experimental groups: (I) untreated; (II) treated daily with M. x piperita L (100 mg/kg) and III) treated on 1/42/43 days post-infection with Praziquantel (500 mg/kg). Another group with uninfected and untreated mice was used as a control. Subsequently, seven weeks post-infection, S. mansoni eggs were counted in the feces, liver and intestine. Worms were recovered by perfusion of the hepatic portal system and counted. Sera levels of IL-10, IL-5, IL-13, IFN-gamma, IgG1, IgE and IgG2a were assayed by ELISA. Animals treated with a daily dose of M. x piperita L showed increased sera levels of IL-10, IFN-gamma, IgG2a and IgE. Besides, M. x piperita L. treatment promoted reduction in parasite burden by 35.2% and significant decrease in egg counts in the feces and intestine. (C) 2014 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Morfol & Patol, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Pharmaceut Sci, Dept Nat Prod & Toxicol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Nova Lisboa, Unidade Parasitol & Microbiol Med, Unidade Ensino & Invest Parasitol Med, Grp Helmintol & Malacol Med,Inst Higiene & Med Tr, P-1349008 Lisbon, Portugal
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Pharmaceut Sci, Dept Nat Prod & Toxicol, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 10/11.606-9
dc.format.extent627-632
dc.identifierhttp://dx.doi.org/10.1016/j.imbio.2014.03.015
dc.identifier.citationImmunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 219, n. 8, p. 627-632, 2014.
dc.identifier.doi10.1016/j.imbio.2014.03.015
dc.identifier.issn0171-2985
dc.identifier.urihttp://hdl.handle.net/11449/113484
dc.identifier.wosWOS:000338004500007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofImmunobiology
dc.relation.ispartofjcr2.873
dc.relation.ispartofsjr1,100
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMentha x piperita L.en
dc.subjectSchistosoma mansonien
dc.subjectImmunomodulationen
dc.subjectAntiparasiticen
dc.titleImmunological and parasitological parameters in Schistosoma mansoni-infected mice treated with crude extract from the leaves of Mentha x piperita L.en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Coleções

Artigos - Princípios Ativos Naturais e Toxicologia - FCFAR