Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físico

Página do item simplificado
dc.contributor.advisorLouzada, Mário Jefferson Quirino [UNESP]
dc.contributor.advisorCiarlini, Paulo Cesar [UNESP]
dc.contributor.authorNarciso, Luis Gustavo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-06-11T19:30:23Z
dc.date.available2014-06-11T19:30:23Z
dc.date.issued2013-12-10
dc.description.abstractPhysical inactivity is a public health problem and one of the greatest evils of modern society. Biggest part of the sedentary population practice physical activity sporadically. It is well established that the excess of physical exercise in or non-conditioned people causes oxidative stress and muscle damage. The present study tested the hypothesis that a single session of physical exercise can cause oxidative stress and muscle damage in sedentary rats. Additively, the antioxidant effect of the polyphenol resveratrol (RV) was evaluated, and its ability to attenuate oxidative stress and muscle damage caused by physical activity. For this, 40 sedentary adults rats (Rattus norvegicus Albinus, Wistar) were randomly subjected or not to 90 minutes of swimming, with and without treatment with RV (100mg/kg/14days): N-RV- (n=10) group maintained at rest and not treated with RV, N-RV+ (n=10) group maintained at rest and treated with RV, N+RV- (n=10) group subjected to physical exercise of swimming not treated with RV and N+RV+ (n=10) group submitted to physical exercise of swimming and treated with RV. In sedentary rats, physical activity of swimming promoted oxidative stress (observed by increased lipid peroxidation and decreased total antioxidant capacity of plasma) and significant increase in plasma activity of creatine kinase (CK) and lactate dehydrogenase (LDH). The RV treatment decreased lipid peroxidation and activity of the markers of muscle injury (CK and LDH) in sedentary rats submitted to swimming. This is one of the first evidence that a single session of physical exercise can cause oxidative stress in sedentary individuals and that the RV can be an alternative to alleviate muscle injury caused by this stress
dc.format.extent64 f.
dc.identifier.aleph000743692
dc.identifier.capes33004021075P8
dc.identifier.citationNARCISO, Luis Gustavo. Resveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedendários submetidos à exercício físico: Luis Gustavo Narciso. 64 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, 2013.
dc.identifier.file000743692.pdf
dc.identifier.lattes2925649195052339
dc.identifier.lattes3613940018299500
dc.identifier.orcid0000-0003-1480-5208
dc.identifier.urihttp://hdl.handle.net/11449/99872
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectAntioxidantespt
dc.subjectNataçãopt
dc.subjectStress oxidativopt
dc.subjectRatopt
dc.subjectExercícios físicos aquáticospt
dc.subjectResveratrolpt
dc.titleResveratrol atenua o estresse oxidativo e a lesão muscular de ratos sedentários submetidos à exercício físicopt
dc.typeDissertação de mestrado
unesp.advisor.lattes3613940018299500[2]
unesp.advisor.orcid0000-0003-1480-5208[2]
unesp.author.lattes2925649195052339
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaFisiologia médica e cirúrgicapt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
000743692.pdf
Tamanho:
584.02 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

Dissertações - Ciência Animal - FMVA