Comparison of oxidative stress and the frequency of polymorphisms in the HFE gene between hemoglobin S trait blood donors and sickle cell disease patients

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dc.contributor.authorViana-Baracioli, L. M. S. [UNESP]
dc.contributor.authorTukamoto Junior, N. C. [UNESP]
dc.contributor.authorRicci Junior, O.
dc.contributor.authorMattos, L. C.
dc.contributor.authorAngulo, I. L.
dc.contributor.authorBonini-Domingos, C. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHemoctr
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T15:34:42Z
dc.date.available2014-05-20T15:34:42Z
dc.date.issued2011-01-01
dc.description.abstractIt is well documented that Hb S and iron affect blood cells, and trigger oxidative processes and generation of free radicals with potential for lipid peroxidation. We evaluated the frequency of polymorphisms in the HFE gene in Hb AS blood donors and how these polymorphisms influenced lipid peroxidation and antioxidant capacity. Blood samples were collected from 211 Hb AS blood donors, 119 Hb AA blood donors as a control group, and 28 sickle cell disease patients (Hb SS). The H63D allele was found at a frequency of 10.5% in the Hb AS samples, and the C282Y allele frequency was 0.7%. In the control group, the frequencies of the H63D and C282Y alleles were 13.4 and 2.1%, respectively. In the sickle-cell disease patients, the H63D and the C282Y allele frequencies were 10.7 and 3.5%, respectively. The frequencies of the C282Y and H63D polymorphisms in Hb AS blood donors are similar to those reported for the Brazilian population. Serum malondialdehyde values, indicative of lipid peroxidation, were highest in sickle cell patients, independent of the polymorphisms in the HFE gene, with significant differences, showing the influence of Hb S allele in the levels of lipid peroxidation. However, the trolox equivalent antioxidant capacity average levels, indicative of the antioxidant capacity, were reduced with significant differences, indicating that in spite of a lipid peroxidation raise, this is not followed by the increased of the antioxidant capacity, leading to oxidative stress.en
dc.description.affiliationUniv Estadual São Paulo Julio de Mesquita Filho, Inst Biociencias Letras & Ciencias Exatas, Lab Hemoglobinas & Genet Doencas Hematol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationHemoctr, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Hemoctr Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual São Paulo Julio de Mesquita Filho, Inst Biociencias Letras & Ciencias Exatas, Lab Hemoglobinas & Genet Doencas Hematol, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent3446-3454
dc.identifierhttp://dx.doi.org/10.4238/2011.December.8.4
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 10, n. 4, p. 3446-3454, 2011.
dc.identifier.doi10.4238/2011.December.8.4
dc.identifier.fileWOS000300617600119.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes3279428066176719
dc.identifier.orcid0000-0002-4603-9467
dc.identifier.urihttp://hdl.handle.net/11449/42631
dc.identifier.wosWOS:000300617600119
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHemoglobinopathyen
dc.subjectHemoglobin Sen
dc.subjectAntioxidant capacityen
dc.subjectHFEen
dc.subjectHemochromatosisen
dc.titleComparison of oxidative stress and the frequency of polymorphisms in the HFE gene between hemoglobin S trait blood donors and sickle cell disease patientsen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.author.lattes3279428066176719[6]
unesp.author.orcid0000-0002-8572-8177[4]
unesp.author.orcid0000-0002-4603-9467[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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