Effect of gender on training-induced vascular remodeling in SHR

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dc.contributor.authorAmaral, Sandra Lia do [UNESP]
dc.contributor.authorMichelini, L. C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:26:06Z
dc.date.available2014-05-20T13:26:06Z
dc.date.issued2011-09-01
dc.description.abstractThere is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ between men and women and between male and female animals. This review focuses on peripheral training-induced adaptations that contribute to a blood pressure-lowering effect, with special attention to differential responses in male and female spontaneously hypertensive rats (SHR). Heart, diaphragm and skeletal muscle arterioles (but not kidney arterioles) undergo eutrophic outward remodeling in trained male SHR, which contributed to a reduction of peripheral resistance and to a pressure fall. In contrast, trained female SHR showed no change in arteriole wall-to-lumen ratio and no pressure fall. on the other hand, training-induced adaptive changes in capillaries and venules (increased density) were similar in male and female SHR, supporting a similar hyperemic response to exercise.en
dc.description.affiliationUniv São Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Educ Fis, Fac Ciencias, Bauru, SP, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, Programa Interinst Posgrad UNESP UFSCAR, BR-13560 São Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Educ Fis, Fac Ciencias, Bauru, SP, Brazil
dc.description.affiliationUnespUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, Programa Interinst Posgrad UNESP UFSCAR, BR-13560 São Carlos, SP, Brazil
dc.format.extent814-826
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2011007500055
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 44, n. 9, p. 814-826, 2011.
dc.identifier.fileS0100-879X2011000900001-en.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2011000900001
dc.identifier.urihttp://hdl.handle.net/11449/8359
dc.identifier.wosWOS:000295721500001
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectExercise trainingen
dc.subjectHypertensionen
dc.subjectMicrocirculationen
dc.subjectArteriolesen
dc.subjectCapillariesen
dc.subjectVenulesen
dc.titleEffect of gender on training-induced vascular remodeling in SHRen
dc.typeArtigo
dcterms.rightsHolderAssoc Bras Divulg Cientifica
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentEducação Física - FCpt

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