Telomere length and its relationship with chronic diseases - New perspectives for periodontal research

Página do item simplificado
dc.contributor.authorSteffens, Joao Paulo [UNESP]
dc.contributor.authorMasi, Stefano
dc.contributor.authorD'Aiuto, Francesco
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity College London
dc.contributor.institutionUCL Eastman Dental Institute
dc.date.accessioned2014-05-27T11:28:17Z
dc.date.available2014-05-27T11:28:17Z
dc.date.issued2013-02-01
dc.description.abstractObjective: The ageing process is accompanied by a variety of cellular modifications, and telomere shortening is a common finding. Large epidemiological studies have reported an association between shorter telomere length in peripheral leukocytes and several inflammatory diseases of the elderly including diabetes, atherosclerosis and, recently, periodontitis. The primary aim of this study was to critically discuss available evidence regarding the potential mechanisms relating shorter telomeres to periodontitis. Design: A narrative literature review was performed to report evidence relating shorter telomeres to the ageing process and inflammation. Then, we searched MEDLINE (1950 to May 2012) and ISI WEB OF SCIENCE (1950 to May 2012) databases for the combination of the terms 'telomere' and 'periodontitis'. Results: Although these associations suggest a possible role of telomere attrition in the onset or evolution of chronic inflammatory diseases, only two studies addressed the relationship between telomere length and periodontitis. Conclusion: We suggest that the chronic inflammatory burden observed in people with chronic periodontitis could represent the driver of telomere shortening. However, further evidence is needed to confirm whether inflammation is the cause or the consequence of the shorter leukocyte telomere length observed in people with periodontitis. © 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationDepartment of Physiology and Pathology São Paulo State University School of Dentistry at Araraquara, 1680 Humaitá St., Araraquara 14801-903, SP
dc.description.affiliationVascular Physiology Unit Institute of Child Health University College London, London
dc.description.affiliationPeriodontology Unit Department of Restorative Dental Sciences UCL Eastman Dental Institute, London
dc.description.affiliationUnespDepartment of Physiology and Pathology São Paulo State University School of Dentistry at Araraquara, 1680 Humaitá St., Araraquara 14801-903, SP
dc.format.extent111-117
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.09.009
dc.identifier.citationArchives of Oral Biology, v. 58, n. 2, p. 111-117, 2013.
dc.identifier.doi10.1016/j.archoralbio.2012.09.009
dc.identifier.issn0003-9969
dc.identifier.lattes2640929291808415
dc.identifier.scopus2-s2.0-84874114755
dc.identifier.urihttp://hdl.handle.net/11449/74464
dc.identifier.wosWOS:000314199600001
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAgeing
dc.subjectCell ageing
dc.subjectPeriodontitis
dc.subjectTelomere
dc.titleTelomere length and its relationship with chronic diseases - New perspectives for periodontal researchen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes2640929291808415
unesp.author.orcid0000-0002-6071-553X[1]
unesp.author.orcid0000-0002-0592-542X[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

Arquivos

Coleções

Artigos - Fisiologia e Patologia - FOAR