In Vitro Ultrasound Influence on Cutaneous Permeation of Hyaluronidase

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dc.contributor.authorZague, Vivian
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorOzores Polacow, Maria Luiza
dc.contributor.authorMariani Pires-de-Campos, Maria Silvia
dc.contributor.authorLeonardi, Gislaine Ricci
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Metodista Piracicaba
dc.date.accessioned2014-05-20T13:24:56Z
dc.date.available2014-05-20T13:24:56Z
dc.date.issued2010-01-01
dc.description.abstractIn vitro skin permeation of hyaluronidase enzyme and the ultrasound (US) effects on cutaneous permeation of this enzyme were investigated. Diffusion cell technique, porcine skins, buffer solution, and a hydrophilic gel+hyaluronidase (100 TUR/g), were used for study. The experimental groups were: gel+enzyme and gel+enzyme+US. The activity of permeated hyaluronidase was determined by turbydimetric method in spectrophotometer at 400nm. Gel+enzyme group permitted a diffusion of 26.89 +/- 3.82 TUR of hyaluronidase in the total time of 240 minutes. However, the other group did not produce significant differences (p0.05) in the same period (13.68 +/- 5.35 TUR). Hyaluronidase permeation through the skin was verified; however US did not cause increase of this enzyme permeation.en
dc.description.affiliationSão Paulo State Univ, UNESP, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, São Paulo, Brazil
dc.description.affiliationUniv Metodista Piracicaba, Fac Hlth Sci, Piracicaba, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Fac Pharmaceut Sci, Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent756-759
dc.identifierhttp://dx.doi.org/10.1080/01932690903333051
dc.identifier.citationJournal of Dispersion Science and Technology. Philadelphia: Taylor & Francis Inc, v. 31, n. 6, p. 756-759, 2010.
dc.identifier.doi10.1080/01932690903333051
dc.identifier.issn0193-2691
dc.identifier.urihttp://hdl.handle.net/11449/7870
dc.identifier.wosWOS:000277725200009
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Dispersion Science and Technology
dc.relation.ispartofjcr1.454
dc.relation.ispartofsjr0,375
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHyaluronidaseen
dc.subjectin vitro cutaneous permeationen
dc.subjectultrasounden
dc.titleIn Vitro Ultrasound Influence on Cutaneous Permeation of Hyaluronidaseen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Inc
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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