Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review

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dc.contributor.authorNogueira, Marcelo Fábio Gouveia [UNESP]
dc.contributor.authorFernandes, Paulo [UNESP]
dc.contributor.authorEreno, Ronaldo Luiz [UNESP]
dc.contributor.authorSimões, Renato Arantes Lima [UNESP]
dc.contributor.authorBuratini Júnior, José [UNESP]
dc.contributor.authorBarros, Ciro Moraes [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-21T17:52:58Z
dc.date.available2015-08-21T17:52:58Z
dc.date.issued2010
dc.description.abstractAcquisition of the luteinizing hormone receptor (LHR) on granulosa cells of the dominant follicle is essential to physiological LH-mediated effects on the final stages of follicular growth, final maturation of the oocyte, ovulation and luteinization of the follicular wall. Therefore, LHR plays a key role in the final maturation of the dominant follicle from follicular dominance to ovulation. In this review, the basic molecular aspects of LHR (gene structure, alternative splicing and ligand mediated activation) and the physiological regulatory aspects (changes in LHR expression during antral follicle growth and a post-transcriptional model for downregulation of LHR transcripts) are addressed. Despite the accumulation of considerable amounts of information about LHR, a comprehensive and broad model for the role of LHR in bovine antral follicle growth is missing. Questions such as the function for alternative LHR transcripts, their transcriptional and translational regulation, and how the transcripts go to the cell surface and interact with ligands remain to be elucidated in bovine and other species.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antônio, 2100, Vila Glória, CEP 19800000, SP, Brasil
dc.description.affiliationUnespDept. of Biological Sciences, College of Sciences and Letters, UNESP, Campus Assis, SP, Brazil
dc.description.affiliationUnespDept. Pharmacology Biosciences Institute, UNESP, Campus Botucatu, SP, Brazil
dc.description.affiliationUnespDept. Physiology, Biosciences Institute, UNESP, Campus Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMFGN
dc.description.sponsorshipIdMFGN - 2001/08743-5
dc.format.extent51-64
dc.identifierhttp://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.html
dc.identifier.citationAnimal Reproduction, v. 7, n. 2, p. 51-64, 2010.
dc.identifier.fileISSN1806-9614-2010-07-02-51-64.pdf
dc.identifier.issn1806-9614
dc.identifier.lattes3734933152414412
dc.identifier.lattes7795883009987806
dc.identifier.urihttp://hdl.handle.net/11449/126730
dc.language.isoeng
dc.relation.ispartofAnimal Reproduction
dc.relation.ispartofjcr0.991
dc.relation.ispartofsjr0,308
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectBos indicusen
dc.subjectBos taurusen
dc.subjectCattleen
dc.subjectFolliculogenesisen
dc.subjectGranulosa cellsen
dc.subjectLHRen
dc.subjectLuteinizing hormone receptoren
dc.subjectOvulationen
dc.titleLuteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a reviewen
dc.typeArtigo
unesp.author.lattes3734933152414412
unesp.author.lattes7795883009987806
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Letras, Assispt
unesp.departmentCiências Biológicaspt

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Artigos - Ciências Biológicas - FCLAS
Artigos - Farmacologia - IBB
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