Celecoxib treatment does not alter recruitment and activation of osteoclasts in the initial phase of experimental tooth movement

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dc.contributor.authorCarvalho-Filho, E. P.
dc.contributor.authorStabile, A. C.
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorStuani, M. B. S.
dc.contributor.authorIyomasa, M. M.
dc.contributor.authorRocha, M. J. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:20Z
dc.date.accessioned2014-05-20T13:43:06Z
dc.date.available2013-09-30T18:29:20Z
dc.date.available2014-05-20T13:43:06Z
dc.date.issued2012-01-01
dc.description.abstractIn a previous study, we reported that the short-term treatment with celecoxib, a nonsteroidal anti-inflammatory drug (NSAID) attenuates the activation of brain structures related to nociception and does not interfere with orthodontic incisor separation in rats. The conclusion was that celecoxib could possibly be prescribed for pain in orthodontic patients. However, we did not analyze the effects of this drug in periodontium. The aim of this follow-up study was to analyze effects of celecoxib treatment on recruitment and activation of osteoclasts and alveolar bone resorption after inserting an activated orthodontic appliance between the incisors in our rat model. Twenty rats (400420 g) were pretreated through oral gavage with celecoxib (50 mg/kg) or vehicle (carboxymethylcellulose 0.4%). After 30 min, they received an activated (30 g) orthodontic appliance, set not to cause any palate disjunction. In sham animals, the appliance was immediately removed after introduction. All animals received ground food and, every 12 h, celecoxib or vehicle. After 48 h, they were anesthetized and transcardiacally perfused through the aorta with 4% formaldehyde. Subsequently, maxillae were removed, post-fixed and processed for histomorphometry or immunohistochemical analyses. As expected, incisor distalization induced an inflammatory response with certain histological changes, including an increase in the number of active osteoclasts at the compression side in group treated with vehicle (appliance: 32.2 +/- 2.49 vs sham: 4.8 +/- 1.79, P<0.05) and celecoxib (appliance: 31.0 +/- 1.45 vs sham: 4.6 +/- 1.82, P<0.05). The treatment with celecoxib did not modify substantially the histological alterations and the number of active osteoclasts after activation of orthodontic appliance. Moreover, we did not see any difference between the groups with respect to percentage of bone resorption area. Taken together with our previous results we conclude that short-term treatment with celecoxib can indeed be a therapeutic alternative for pain relieve during orthodontic procedures.en
dc.description.affiliationUniv São Paulo, Dept Morfol Estomatol & Fisiol, Fac Odontol Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Aracatuba, Dept Ciencias Basicas, Aracatuba, Brazil
dc.description.affiliationUniv São Paulo, Dept Pediat & Ortodontia, Fac Odontol Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Aracatuba, Dept Ciencias Basicas, Aracatuba, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent272-276
dc.identifierhttp://dx.doi.org/10.4081/ejh.2012.e43
dc.identifier.citationEuropean Journal of Histochemistry. Pavia: Pagepress Publ, v. 56, n. 4, p. 272-276, 2012.
dc.identifier.doi10.4081/ejh.2012.e43
dc.identifier.fileWOS000313464900005.pdf
dc.identifier.issn1121-760X
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.urihttp://hdl.handle.net/11449/15001
dc.identifier.wosWOS:000313464900005
dc.language.isoeng
dc.publisherPagepress Publ
dc.relation.ispartofEuropean Journal of Histochemistry
dc.relation.ispartofjcr2.217
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectorthodontic treatmenten
dc.subjectanalgesicen
dc.subjectinflammationen
dc.subjectbone resorptionen
dc.subjectosteoclastsen
dc.titleCelecoxib treatment does not alter recruitment and activation of osteoclasts in the initial phase of experimental tooth movementen
dc.typeArtigo
dcterms.licensehttp://www.pagepress.org/open_access.html
dcterms.rightsHolderPagepress Publ
unesp.author.lattes4408095517346846
unesp.author.orcid0000-0003-4859-0583[3]
unesp.author.orcid0000-0001-7791-9144[4]
unesp.author.orcid0000-0002-5102-4550[6]
unesp.author.orcid0000-0002-4001-6440[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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