Absence of RKIP expression is an independent prognostic biomarker for gastric cancer patients

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dc.contributor.authorMartinho, Olga
dc.contributor.authorSimões, Kleber
dc.contributor.authorLongatto-Filho, Adhemar [UNESP]
dc.contributor.authorJacob, Carlos Eduardo
dc.contributor.authorZilberstein, Bruno
dc.contributor.authorBresciani, Cláudio
dc.contributor.authorGama-Rodrigues, Joaquim
dc.contributor.authorCecconello, Ivan
dc.contributor.authorAlves, Venâncio [UNESP]
dc.contributor.authorReis, Rui Manuel
dc.contributor.institutionUniversity of Minho
dc.contributor.institutionICVS/3B's - PT Government Associate Laboratory
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionBarretos Cancer Hospital
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:21Z
dc.date.available2014-05-27T11:28:21Z
dc.date.issued2013-02-01
dc.description.abstractGastric cancer is a leading cause of cancer-related mortality, and the presence of lymph node metastasis an important prognostic factor. Downregulation of RKIP has been associated with tumor progression and metastasis in several types of neoplasms, being currently categorized as a metastasis suppressor gene. Our aim was to determine the expression levels of RKIP in gastric tissues and to evaluate its impact in the clinical outcome of gastric carcinoma patients. RKIP expression levels were studied by immunohistochemistry in a series of gastric tissues. Overall, we analysed 222 non-neoplastic gastric tissues, 152 primary tumors and 42 lymph node metastasis samples. We observed that RKIP was highly expressed in ∼83% of non-neoplastic tissues (including normal tissue and metaplasia), was lost in ∼56% of primary tumors and in ∼90% of lymph node metastasis samples. Loss of RKIP expression was significantly associated with several markers of poor clinical outcome, including the presence of lymph node metastasis. Furthermore, the absence of RKIP protein constitutes an independent prognostic marker for these patients. In conclusion, RKIP expression is significantly lost during gastric carcinoma progression being almost absent in lymph node metastasis samples. Of note, we showed that the absence of RKIP expression is associated with poor outcome features of gastric cancer patients, this being also an independent prognostic marker.en
dc.description.affiliationLife and Health Sciences Research Institute (ICVS) Health Sciences School University of Minho, Braga
dc.description.affiliationICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães
dc.description.affiliationDepartment of Pathology University of São Paulo School of Medicine, São Paulo
dc.description.affiliationMolecular Oncology Research Center Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, CEP 14784400 Barretos, S. Paulo
dc.description.affiliationLaboratory of Medical Investigation (LIM) 14 Faculty of Medicine São Paulo State University, São Paulo
dc.description.affiliationDepartment of Gastroenterology Faculty of Medicine University of São Paulo, São Paulo
dc.description.affiliationUnespLaboratory of Medical Investigation (LIM) 14 Faculty of Medicine São Paulo State University, São Paulo
dc.format.extent690-696
dc.identifierhttp://dx.doi.org/10.3892/or.2012.2179
dc.identifier.citationOncology Reports, v. 29, n. 2, p. 690-696, 2013.
dc.identifier.doi10.3892/or.2012.2179
dc.identifier.file2-s2.0-84872803648.pdf
dc.identifier.issn1021-335X
dc.identifier.issn1791-2431
dc.identifier.scopus2-s2.0-84872803648
dc.identifier.urihttp://hdl.handle.net/11449/74546
dc.identifier.wosWOS:000313605100039
dc.language.isoeng
dc.relation.ispartofOncology Reports
dc.relation.ispartofjcr2.976
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectGastric carcinomas
dc.subjectPrognosis
dc.subjectRKIP
dc.subjectbiological marker
dc.subjectphosphatidylethanolamine binding protein
dc.subjectadult
dc.subjectaged
dc.subjectcancer grading
dc.subjectcancer incidence
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmetaplasia
dc.subjectprimary tumor
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectstomach cancer
dc.subjectstomach carcinoma
dc.subjecttissue microarray
dc.subjecttumor volume
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCarcinoma
dc.subjectChi-Square Distribution
dc.subjectFemale
dc.subjectHumans
dc.subjectKaplan-Meier Estimate
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPhosphatidylethanolamine Binding Protein
dc.subjectProportional Hazards Models
dc.subjectStomach Neoplasms
dc.subjectTumor Markers, Biological
dc.titleAbsence of RKIP expression is an independent prognostic biomarker for gastric cancer patientsen
dc.typeArtigo
dcterms.licensehttp://www.spandidos-publications.com/pages/terms

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