Loss of sleep spindle frequency deceleration in Obstructive Sleep Apnea

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dc.contributor.authorCarvalho, Diego Z.
dc.contributor.authorGerhardt, Günther J.L.
dc.contributor.authorDellagustin, Guilherme
dc.contributor.authorde Santa-Helena, Emerson
dc.contributor.authorLemke, Ney
dc.contributor.authorSegal, Alan Z.
dc.contributor.authorSchönwald, Suzana V.
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:03Z
dc.date.available2014-05-27T11:30:03Z
dc.date.issued2013-07-29
dc.description.abstractObjective: Sleep spindles have been suggested as surrogates of thalamo-cortical activity. Internal frequency modulation within a spindle's time frame has been demonstrated in healthy subjects, showing that spindles tend to decelerate their frequency before termination. We investigated internal frequency modulation of slow and fast spindles according to Obstructive Sleep Apnea (OSA) severity and brain topography. Methods: Seven non-OSA subjects and 21 patients with OSA contributed with 30 min of Non-REM sleep stage 2, subjected to a Matching pursuit procedure with Gabor chirplet functions for automatic detection of sleep spindles and quantification of sleep spindle internal frequency modulation (chirp rate). Results: Moderate OSA patients showed an inferior percentage of slow spindles with deceleration when compared to Mild and Non-OSA groups in frontal and parietal regions. In parietal regions, the percentage of slow spindles with deceleration was negatively correlated with global apnea-hypopnea index (r s = -0.519, p = 0.005). Discussion: Loss of physiological sleep spindle deceleration may either represent a disruption of thalamo-cortical loops generating spindle oscillations or some compensatory mechanism, an interesting venue for future research in the context of cognitive dysfunction in OSA. Significance: Quantification of internal frequency modulation (chirp rate) is proposed as a promising approach to advance description of sleep spindle dynamics in brain pathology. © 2013 International Federation of Clinical Neurophysiology.en
dc.identifierhttp://dx.doi.org/10.1016/j.clinph.2013.07.005
dc.identifier.citationClinical Neurophysiology.
dc.identifier.doi10.1016/j.clinph.2013.07.005
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.lattes7977035910952141
dc.identifier.scopus2-s2.0-84880446987
dc.identifier.urihttp://hdl.handle.net/11449/76067
dc.identifier.wosWOS:000329672800015
dc.language.isoeng
dc.relation.ispartofClinical Neurophysiology
dc.relation.ispartofjcr3.614
dc.relation.ispartofsjr1,561
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectChirp
dc.subjectEEG
dc.subjectMatching pursuit
dc.subjectOSA
dc.subjectSleep
dc.subjectSpindle
dc.titleLoss of sleep spindle frequency deceleration in Obstructive Sleep Apneaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes7977035910952141
unesp.author.orcid0000-0002-8822-1638[1]
unesp.author.orcid0000-0001-7463-4303[5]
unesp.author.orcid0000-0002-9020-2663[3]

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