Association between JY-1 gene polymorphisms and reproductive traits in beef cattle

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dc.contributor.authorFerreira de Camargo, Gregorio Miguel [UNESP]
dc.contributor.authorCosta, Raphael Bermal [UNESP]
dc.contributor.authorAlbuquerque, Lucia Galvao de [UNESP]
dc.contributor.authorAlmeida Regitano, Luciana Correia de
dc.contributor.authorBaldi, Fernando [UNESP]
dc.contributor.authorTonhati, Humberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2014-12-03T13:11:34Z
dc.date.available2014-12-03T13:11:34Z
dc.date.issued2014-01-10
dc.description.abstractReproductive traits have a high economic value and it is interesting to include them in the selection objectives of an animal breeding program. These traits generally show low heritability and molecular markers may therefore be used in genetic evaluations to improve the accuracy of predictions. The JY-1 gene is expressed in the oocyte and it is associated with folliculogenesis and early embryo development. It has been suggested to affect reproductive traits. In this study, exons 1 and 2 of the JY-1 gene were studied in 385 Nellore females by PCR-sequencing. Seventeen polymorphisms were identified. After analysis of linkage disequilibrium, association tests were performed between eight SNPs and the occurrence of early pregnancy, age at first calving, days to calving, and reconception of primiparous heifers. Seven SNPs were significant for three traits. The most significant was chr29:12,999 T/A (p = 0.003) which was associated with the occurrence of early pregnancy. This SNP might be involved in protein translation inhibition since it affects the initial methionine codon. The JY-1, an oocyte specific gene, influences reproductive traits; further studies investigating other regions of the gene or other genes expressed in tissues of the female reproductive system would be interesting to be performed. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Unesp, Fac Ciencias Agr & Vet, Dept Zootecnia, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationEmpresa Brasileira Pesquisa Agr Embrapa, Ctr Pecuaria Sudeste, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Unesp, Fac Ciencias Agr & Vet, Dept Zootecnia, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent477-480
dc.identifierhttp://dx.doi.org/10.1016/j.gene.2013.09.126
dc.identifier.citationGene. Amsterdam: Elsevier Science Bv, v. 533, n. 2, p. 477-480, 2014.
dc.identifier.doi10.1016/j.gene.2013.09.126
dc.identifier.issn0378-1119
dc.identifier.lattes7445254960858159
dc.identifier.urihttp://hdl.handle.net/11449/113269
dc.identifier.wosWOS:000327829100003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofGene
dc.relation.ispartofjcr2.498
dc.relation.ispartofsjr1,019
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectInitial methionineen
dc.subjectNelloreen
dc.subjectPCR-sequencingen
dc.subjectSNPen
dc.titleAssociation between JY-1 gene polymorphisms and reproductive traits in beef cattleen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7445254960858159
unesp.author.orcid0000-0002-2030-7590[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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