Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi

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dc.contributor.authorPoliti, Flavio A. S. [UNESP]
dc.contributor.authorde Mello, Joao C. P.
dc.contributor.authorMigliato, Ketylin F. [UNESP]
dc.contributor.authorNepomuceno, Andrea L. A. [UNESP]
dc.contributor.authorMoreira, Raquel Regina Duarte [UNESP]
dc.contributor.authorPietro, Rosemeire C. L. R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.date.accessioned2014-05-20T13:25:29Z
dc.date.available2014-05-20T13:25:29Z
dc.date.issued2011-04-01
dc.description.abstractEndopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi.en
dc.description.affiliationUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, BR-502 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Estadual de Maringá (UEM), Dept Pharm, BR-87020900 Maringa, PR, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Dept Nat Act Principles & Toxicol, BR-502 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, BR-502 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Pharmaceut Sci Araraquara, Dept Drugs & Med, Dept Nat Act Principles & Toxicol, BR-502 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent2757-2768
dc.identifierhttp://dx.doi.org/10.3390/ijms12042757
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 12, n. 4, p. 2757-2768, 2011.
dc.identifier.doi10.3390/ijms12042757
dc.identifier.fileWOS000289974600018.pdf
dc.identifier.issn1661-6596
dc.identifier.lattes7710344461864924
dc.identifier.orcid0000-0002-4253-0320
dc.identifier.urihttp://hdl.handle.net/11449/8069
dc.identifier.wosWOS:000289974600018
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectEndopleura uchien
dc.subjectminimum inhibitory concentrationen
dc.subjectIC(50)en
dc.subjecttanninsen
dc.titleAntimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchien
dc.typeArtigo
dcterms.licensehttp://www.mdpi.com/about/openaccess
dcterms.rightsHolderMdpi Ag
unesp.author.lattes7710344461864924[5]
unesp.author.orcid0000-0001-6321-5509[1]
unesp.author.orcid0000-0002-7532-3395[2]
unesp.author.orcid0000-0001-7859-8127[6]
unesp.author.orcid0000-0002-4253-0320[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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