Effects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice

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dc.contributor.authorOliveira, Rodrigo Juliano
dc.contributor.authorSparca Salles, Maria Jose
dc.contributor.authorda Silva, Ariane Fernanda
dc.contributor.authorNakamura Kanno, Tatiane Yumi
dc.contributor.authordos Santos Lourenco, Ana Carolina
dc.contributor.authorFreiria, Gabriele Antico
dc.contributor.authorMatiazi, Hevenilton Jose
dc.contributor.authorRibeiro, Lucia Regina [UNESP]
dc.contributor.authorMantovani, Mario Sergio
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:55:27Z
dc.date.available2014-05-20T13:55:27Z
dc.date.issued2009-04-01
dc.description.abstractAlterations that could lead to the cancer development may also be related to an adverse development of offspring in experimental animals. Some functional foods, which contain the polysaccharide beta-glucan, have been described as being effective in the prevention of clastogenic damage. Based on that finding, the aim of the present study was to determine the efficacy of this sugar polymer in the mutagenic and teratogenic damage control. Two sets of females, pregnant and non-pregnant, were evaluated. The results indicated that p-glucan was effective in preventing clastogenic damage in pregnant as well as non-pregnant females. In addition, pregnant females were more susceptible to mutagenic damage. However, teratogenic effects were not prevented effectively, although there was a trend toward a reduction in level of malformations. Despite beta-glucan did not prevent malformations, it increased fetal viability and reduced number of post-implantation losses and resorption, thereby enhancing reproductive performance in females. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Ctr Biol Sci, Dept Biol, Londrina, PR USA
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Lab Food & Drugs Technol, Londrina, PR USA
dc.description.affiliationState Univ São Paulo, Dept Biol, Rio Claro, SP, Brazil
dc.description.affiliationUnespState Univ São Paulo, Dept Biol, Rio Claro, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná (FAADCT/PR)
dc.format.extent164-173
dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2008.12.007
dc.identifier.citationRegulatory Toxicology and Pharmacology. San Diego: Academic Press Inc. Elsevier B.V., v. 53, n. 3, p. 164-173, 2009.
dc.identifier.doi10.1016/j.yrtph.2008.12.007
dc.identifier.issn0273-2300
dc.identifier.urihttp://hdl.handle.net/11449/19842
dc.identifier.wosWOS:000264851500003
dc.language.isoeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relation.ispartofRegulatory Toxicology and Pharmacology
dc.relation.ispartofjcr2.815
dc.relation.ispartofsjr0,812
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbeta-Glucanen
dc.subjectTeratogenicityen
dc.subjectCyclophosphamideen
dc.subjectMutagenicen
dc.titleEffects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in miceen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderAcademic Press Inc. Elsevier B.V.
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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