Bone healing in drill hole defects in spontaneously hypertensive male and female rats' femurs. A histological and histometric study

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dc.contributor.authorPereira, Andresa Costa [UNESP]
dc.contributor.authorFernandes, Raquel Guedes [UNESP]
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.authorBalducci, Ivan [UNESP]
dc.contributor.authorFaig-Leite, Horacio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:25:16Z
dc.date.available2014-05-20T15:25:16Z
dc.date.issued2007-01-01
dc.description.abstractObjective: the aim of this study was to evaluate the bone healing in spontaneously hypertensive rats (SHR) and compare the results with normotensive rats, evaluating male and female animals.Methods: A bone drill defect was created in the left femur of 24 SHR (12 males and 12 females) and 24 normotensive rats (12 males and 12 females). The animals were divided into two groups and sacrificed 7 and 21 days after the surgical procedure. After the routine laboratory processing, histological and histometric analysis were carried out and data were submitted to ANOVA and Tukey's test (5%).Results: Males and females from the same group had similar histological characteristics. After seven days, all animals presented irregular bone trabeculae. The periosteal osteoblasts were flattened in SHR, and presented a cuboid shape in normotensive animals. After 21 days, the bone defects of all specimens showed a linear closure in all the superficial extension. In addition, SHR presented flattened osteoblasts surrounding the bone trabeculae, while normotensive ones showed cuboidal cells. Statistical analysis of the histometric data indicated similar means between the male and female groups, except for normotensive rats on day 7. In addition, a larger amount of new bone formation was observed in hypertensive when compared to normotensive rats on day 27, in males as well as females.Conclusion: We conclude that bone healing in SHR was more significant than in normotensive ones, as shown by the histological and histometric evaluation 21 days after surgery.en
dc.description.affiliationUNESP, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUNESP, Sao Jose Dos Campos, SP, Brazil
dc.format.extent104-109
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2007000100017
dc.identifier.citationArquivos Brasileiros de Cardiologia. São Paulo: Arquivos Brasileiros Cardiologia, v. 88, n. 1, p. 104-109, 2007.
dc.identifier.doi10.1590/S0066-782X2007000100017
dc.identifier.fileWOS000253886000017.pdf
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.lattes6967369119792151
dc.identifier.scieloS0066-782X2007000100017
dc.identifier.scopus2-s2.0-34748865935
dc.identifier.urihttp://hdl.handle.net/11449/35705
dc.identifier.wosWOS:000253886000017
dc.language.isopor
dc.language.isoeng
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectfemur/abnormalitiespt
dc.subjecthypertensionpt
dc.subjectratspt
dc.subjectinbred (SHR)pt
dc.titleBone healing in drill hole defects in spontaneously hypertensive male and female rats' femurs. A histological and histometric studyen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/paboutj.htm
dcterms.rightsHolderArquivos Brasileiros Cardiologia
unesp.author.lattes6967369119792151
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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