Involvement of Glutathione, Sulfhydryl Compounds, Nitric Oxide, Vasoactive Intestinal Peptide, and Heat-Shock Protein-70 in the Gastroprotective Mechanism of Croton cajucara Benth. (Euphorbiaceae) Essential Oil

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dc.contributor.authorRozza, Ariane Leite [UNESP]
dc.contributor.authorMoraes, Thiago de Mello [UNESP]
dc.contributor.authorKushima, Helio [UNESP]
dc.contributor.authorNunes, Domingos Savio
dc.contributor.authorHiruma-Lima, Clélia Akiko [UNESP]
dc.contributor.authorPellizzon, Claudia Helena [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Estadual Ponta Grossa
dc.date.accessioned2014-05-20T13:50:00Z
dc.date.available2014-05-20T13:50:00Z
dc.date.issued2011-09-01
dc.description.abstractThis study aimed to evaluate the gastroprotective mechanism of action of the essential oil of Croton cajucara Benth. (Euphorbiaceae) stem bark in ethanol-induced gastric ulcers and its in vitro anti-Helicobacter pylori activity. The involvement of heat-shock protein-70, vasoactive intestinal peptide, glutathione, nitric oxide, and nonprotein sulfhydryl compounds in the gastroprotective effect was determined in male Wistar rats. The minimum inhibitory concentration against H. pylori was determined in vitro. The results were analyzed by analysis of variance followed by the Dunnett test, and a P value less than 0.05 was considered to represent a statistically significant difference. C. cajucara decreased ethanol-induced ulcer area in 100% of ulcers and decreased the histologic lesions. In the C. cajucara group, the area marked by heat-shock protein-70 was significantly higher than the area in the control group; this finding was not seen for vasoactive intestinal peptide. C. cajucara could not maintain glutathione levels close to those in the sham group. The gastric ulcer area of rats treated with the sulfhydryl compound blocker was decreased, but the ulcer area of rats treated with nitric oxide synthase inhibitor showed no alteration. The minimum inhibitory concentration obtained for C. cajucara was 125 mu g/mL. These findings suggest that sulfhydryl compounds and heat-shock protein-70, but not nitric oxide, glutathione, or vasoactive intestinal peptide, are involved in the C. cajucara gastroprotective effect against ethanol-induced gastric ulcers.en
dc.description.affiliationUniv Estadual Paulista, Dept Morphol, Biosci Inst, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Physiol, Biosci Inst, São Paulo, Brazil
dc.description.affiliationUniv Estadual Ponta Grossa, Dept Chem, Ponta Grossa, Parana, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Morphol, Biosci Inst, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Physiol, Biosci Inst, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/531283
dc.description.sponsorshipIdFAPESP: 06/55542-9
dc.format.extent1011-1017
dc.identifierhttp://dx.doi.org/10.1089/jmf.2010.0173
dc.identifier.citationJournal of Medicinal Food. New Rochelle: Mary Ann Liebert Inc., v. 14, n. 9, p. 1011-1017, 2011.
dc.identifier.doi10.1089/jmf.2010.0173
dc.identifier.fileWOS000294111400018.pdf
dc.identifier.issn1096-620X
dc.identifier.lattes0019393779801069
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.urihttp://hdl.handle.net/11449/17832
dc.identifier.wosWOS:000294111400018
dc.language.isoeng
dc.publisherMary Ann Liebert, Inc.
dc.relation.ispartofJournal of Medicinal Food
dc.relation.ispartofjcr1.954
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCroton cajucaraen
dc.subjectessential oilen
dc.subjectgastroprotectionen
dc.subjectglutathioneen
dc.subjectheat-shock protein-70en
dc.subjectmedicinal plantsen
dc.subjectnitric oxideen
dc.subjectsulfhydryl compoundsen
dc.titleInvolvement of Glutathione, Sulfhydryl Compounds, Nitric Oxide, Vasoactive Intestinal Peptide, and Heat-Shock Protein-70 in the Gastroprotective Mechanism of Croton cajucara Benth. (Euphorbiaceae) Essential Oilen
dc.typeArtigo
dcterms.licensehttp://www.liebertpub.com/reprints/journal-of-medicinal-food/38/
dcterms.rightsHolderMary Ann Liebert Inc.
unesp.author.lattes2328604224911233[1]
unesp.author.lattes0019393779801069[6]
unesp.author.lattes3814504901386844[5]
unesp.author.orcid0000-0002-4198-0135[1]
unesp.author.orcid0000-0002-8645-3777[5]
unesp.author.orcid0000-0002-4494-4180[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Morfologia - IBB