Asymptomatic carriers of Plasmodium spp. as infection source for malaria vector mosquitoes in the Brazilian Amazon

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dc.contributor.authorAlves, Fabiana Piovesan
dc.contributor.authorGil, Luiz Herman S.
dc.contributor.authorMarrelli, Mauro T.
dc.contributor.authorRibolla, Paulo E. M. [UNESP]
dc.contributor.authorCamargo, Erney P.
dc.contributor.authorDa Silva, Luiz Hildebrando Pereira
dc.contributor.institutionCentro de Pesquisa em Medicina Tropical
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:37Z
dc.date.available2014-05-27T11:21:37Z
dc.date.issued2005-09-01
dc.description.abstractWe have described the existence of asymptomatic carriers of Plasmodium vivax and Plasmodium falciparum infections in native Amazon populations. Most of them had low parasitemias, detected only by polymerase chain reaction (PCR). Because they remain symptomless and untreated, we wanted to determine whether they could infect Anopheles darlingi Root, the main Brazilian vector, and act as disease reservoirs. Fifteen adult asymptomatic patients (PCR positive only) were selected, and experimental infections of mosquitoes were performed by direct feeding and by a membrane-feeding system. Seventeen adult symptomatic patients with high parasitemias were used as controls. We found an infection rate in An. darlingi of 1.2% for the asymptomatic carriers and 22% for the symptomatic carriers. Although the asymptomatic group infected mosquitoes at a much lower rate, these patients remain infective longer than treated, symptomatic patients. Also, the prevalence of asymptomatic infections is 4 to 5 times higher than symptomatic infections among natives. These results have implications for the malaria control program in Brazil, which focuses essentially on the treatment of symptomatic patients. © 2005 Entomological Society of America.en
dc.description.affiliationCentro de Pesquisa em Medicina Tropical, BR-364 Km 4,5, 78910-210, Porto Velho, Rondonia
dc.description.affiliationDepartment of Parasitology University of São Paulo, Av. Lineu Prestes, 1374, 05508-900, São Paulo, S.P.
dc.description.affiliationDepartment of Parasitology São Paulo State University, Botucatu, S.P.
dc.description.affiliationUnespDepartment of Parasitology São Paulo State University, Botucatu, S.P.
dc.format.extent777-779
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/16363160
dc.identifier.citationJournal of Medical Entomology, v. 42, n. 5, p. 777-779, 2005.
dc.identifier.issn0022-2585
dc.identifier.lattes3577149748456880
dc.identifier.orcid0000-0001-8735-6090
dc.identifier.scopus2-s2.0-25444469896
dc.identifier.urihttp://hdl.handle.net/11449/68408
dc.identifier.wosWOS:000231846500008
dc.language.isoeng
dc.relation.ispartofJournal of Medical Entomology
dc.relation.ispartofjcr1.968
dc.relation.ispartofsjr0,962
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnopheles darlingi
dc.subjectAsymptomatic infection
dc.subjectMalaria
dc.subjectMosquito feeding
dc.subjectanimal
dc.subjectAnopheles
dc.subjectBrazil
dc.subjectcomparative study
dc.subjectdisease carrier
dc.subjectdisease transmission
dc.subjectgenetics
dc.subjecthuman
dc.subjectmalaria
dc.subjectparasitology
dc.subjectPlasmodium
dc.subjectpolymerase chain reaction
dc.subjectspecies difference
dc.subjectAnimals
dc.subjectDisease Reservoirs
dc.subjectHumans
dc.subjectInsect Vectors
dc.subjectPolymerase Chain Reaction
dc.subjectSpecies Specificity
dc.subjectPlasmodium falciparum
dc.subjectPlasmodium vivax
dc.titleAsymptomatic carriers of Plasmodium spp. as infection source for malaria vector mosquitoes in the Brazilian Amazonen
dc.typeArtigo
dcterms.licensehttp://www.ingentaconnect.com/about/terms
unesp.author.lattes3577149748456880[4]
unesp.author.orcid0000-0003-0011-5871[5]
unesp.author.orcid0000-0001-8735-6090[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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