Monosodium glutamate in standard and high-fiber diets: Metabolic syndrome and oxidative stress in rats

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dc.contributor.authorDiniz, Yeda Sant'
dc.contributor.authorFaine, Luciane A.
dc.contributor.authorGalhardi, Cristiano M.
dc.contributor.authorRodrigues, Hosana G.
dc.contributor.authorEbaid, Geovana X.
dc.contributor.authorBurneiko, Regina C.
dc.contributor.authorCicogna, Antonio C.
dc.contributor.authorNovelli, Ethel L. B.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:20Z
dc.date.available2014-05-27T11:21:20Z
dc.date.issued2005-06-01
dc.description.abstractObjective: This study determined the effects of adding monosodium glutamate (MSG) to a standard diet and a fiber-enriched diet on glucose metabolism, lipid profile, and oxidative stress in rats. Methods: Male Wistar rats (65 ± 5 g, n = 8) were fed a standard diet (control), a standard diet supplemented with 100 g of MSG per kilogram of rat body weight, a diet rich in fiber, or a diet rich in fiber supplemented with 100 g of MSG per kilogram of body weight. After 45 d of treatment, sera were analyzed for concentrations of insulin, leptin, glucose, triacylglycerol, lipid hydroperoxide, and total antioxidant substances. A homeostasis model assessment index was estimated to characterize insulin resistance. Results: Voluntary food intake was higher and feed efficiency was lower in animals fed the standard diet supplemented with MSG than in those fed the control, fiber-enriched, or fiber- and MSG-enriched diet. The MSG group had metabolic dysfunction characterized by increased levels of glucose, triacylglycerol, insulin, leptin, and homeostasis model assessment index. The adverse effects of MSG were related to an imbalance between the oxidant and antioxidant systems. The MSG group had increased levels of lipid hydroperoxide and decreased levels of total antioxidant substances. Levels of triacylglycerol and lipid hydroperoxide were decreased in rats fed the fiber-enriched and fiber- and MSG-enriched diets, whereas levels of total antioxidant substances were increased in these animals. Conclusions: MSG added to a standard diet increased food intake. Overfeeding induced metabolic disorders associated with oxidative stress in the absence of obesity. The fiber-enriched diet prevented changes in glucose, insulin, leptin, and triacylglycerol levels that were seen in the MSG group. Because the deleterious effects of MSG, i.e., induced overfeeding, were not seen in the animals fed the fiber-enriched diets, it can be concluded that fiber supplementation is beneficial by discouraging overfeeding and improving oxidative stress that is induced by an MSG diet. © 2005 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment of Clinical Cardiology Faculty of Medicine University of São Paulo State, Botucatu, São Paulo
dc.description.affiliationDepartment of Chemistry and Biochemistry Institute of Biological Sciences University of São Paulo State, Botucatu, São Paulo
dc.format.extent749-755
dc.identifierhttp://dx.doi.org/10.1016/j.nut.2004.10.013
dc.identifier.citationNutrition, v. 21, n. 6, p. 749-755, 2005.
dc.identifier.doi10.1016/j.nut.2004.10.013
dc.identifier.issn0899-9007
dc.identifier.scopus2-s2.0-19544377683
dc.identifier.urihttp://hdl.handle.net/11449/68248
dc.language.isoeng
dc.relation.ispartofNutrition
dc.relation.ispartofjcr3.734
dc.relation.ispartofsjr1,300
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectDiets
dc.subjectFiber
dc.subjectMetabolic parameters
dc.subjectMonosodium glutamate
dc.subjectOxidative stress
dc.subjectRats
dc.subjectantioxidant
dc.subjectglucose
dc.subjectglutamate sodium
dc.subjectinsulin
dc.subjectleptin
dc.subjectlipid hydroperoxide
dc.subjecttriacylglycerol
dc.subjectanimal experiment
dc.subjectblood analysis
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectfood intake
dc.subjectglucose blood level
dc.subjectglucose metabolism
dc.subjecthigh fiber diet
dc.subjectinsulin blood level
dc.subjectinsulin resistance
dc.subjectlipid analysis
dc.subjectmale
dc.subjectmetabolic syndrome X
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpriority journal
dc.subjectprotein blood level
dc.subjectrat
dc.subjecttriacylglycerol blood level
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectDietary Fiber
dc.subjectEnergy Intake
dc.subjectFood Additives
dc.subjectInsulin
dc.subjectLeptin
dc.subjectLipid Metabolism
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectOxidative Stress
dc.subjectRandom Allocation
dc.subjectRats, Wistar
dc.subjectSodium Glutamate
dc.subjectTriglycerides
dc.subjectAnimalia
dc.subjectRattus norvegicus
dc.titleMonosodium glutamate in standard and high-fiber diets: Metabolic syndrome and oxidative stress in ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes9418970103564137[7]
unesp.author.orcid0000-0002-4402-6523[7]

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