Lateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in rats

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dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorThunhorst, R. L.
dc.contributor.authorJohnson, A. K.
dc.contributor.institutionUNIV IOWA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:15Z
dc.date.available2014-05-20T15:21:15Z
dc.date.issued1996-01-01
dc.description.abstractThis study investigated the effects of bilateral injections of serotonergic receptor agonist and antagonist into the lateral parabrachial nucleus (LPBN) on the ingestion of water and 0.3 M NaCl induced by intracerebroventricular angiotensin II (ANG II) or by combined subcutaneous injections of the diuretic furosemide (Furo) and the angiotensin-converting enzyme inhibitor captopril (Cap). Rats had stainless steel cannulas implanted bilaterally into the LPBN and into the left lateral ventricle. Bilateral LPBN pretreatment with the serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (4 mu g/200 nl each site) increased 0.3 M NaCl and water intakes induced by intracerebroventricular ANG II (50 ng/mu l) and 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with bilateral LPBN injections of a serotonergic 5-HT2A/2C receptor agonist DOI (5 mu g/200 nl) significantly reduced 0.3 M NaCl intake induced by subcutaneous Furo + Cap. Pretreatment with methysergide or DOI into the LPBN produced no significant changes in the water intake induced by subcutaneous Furo + Cap. These results suggest that serotonergic mechanisms associated with the LPBN may have inhibitory roles in water and sodium ingestion in rats.en
dc.description.affiliationUNIV IOWA, DEPT PHARMACOL, IOWA CITY, IA 52242 USA
dc.description.affiliationUNIV IOWA, CTR CARDIOVASC, IOWA CITY, IA 52242 USA
dc.description.affiliationPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.format.extentR162-R168
dc.identifierhttp://ajpregu.physiology.org/content/270/1/R162
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 270, n. 1, p. R162-R168, 1996.
dc.identifier.issn0363-6119
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/32416
dc.identifier.wosWOS:A1996TT09700021
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectangiotensin IIpt
dc.subjectwater intakept
dc.subjectsalt intakept
dc.subjectfurosemidept
dc.subjectsodium chloride intakept
dc.titleLateral parabrachial nucleus and serotonergic mechanisms in the control of salt appetite in ratsen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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