Doxorubicin induced dilated cardiomyopathy in a rabbit model: An update

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dc.contributor.authorGava, Fábio N. [UNESP]
dc.contributor.authorZacché, Evandro [UNESP]
dc.contributor.authorOrtiz, Edna M.G. [UNESP]
dc.contributor.authorChampion, Tatiana [UNESP]
dc.contributor.authorBandarra, Marcio B. [UNESP]
dc.contributor.authorVasconcelos, Rosemeri O. [UNESP]
dc.contributor.authorBarbosa, José C. [UNESP]
dc.contributor.authorCamacho, Aparecido A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:18Z
dc.date.available2014-05-27T11:28:18Z
dc.date.issued2013-02-01
dc.description.abstractDilated cardiomyopathy (DCM) is characterized by chamber dilation and cardiac dysfunction. Because of the poor prognosis, models are needed for the investigation of and development of new therapeutic approaches, as well as stem cell therapy. Doxorubicin (DOX), used as chemotherapeutic agent, is reported to be cumulative cardiotoxic causing DCM. The aim of the study was to investigate the onset of systolic dysfunction using echocardiography in rabbits receiving two different doses of DOX (1. mg/kg twice a week and 2. mg/kg once a week). Twenty rabbits were treated with doxorubicin in two different doses for 6. weeks and compared with a control group treated with NaCl 0.9%. The effect of doxorubicin on the myocardium was investigated with histological analysis and scanning electron microscopy of left ventricle (LV), as well as in the interventricular septum (IVS) and right ventricle (RV). The results showed a high mortality rate for rabbits receiving 2. mg/kg once a week. A significant reduction in systolic function was present in animals treated with DOX after 6. weeks, with decreased ejection fraction and shortening fraction. Histology and electron microscopy revealed vacuolization, intracytoplasmic granulation, necrosis and interstitial fibrosis in LV, as well as in the IVS and RV. Doxorubicin induced changes are present in the LV, RV and IVS, and the administration at the dose of 1. mg/kg twice a week for only 6. weeks is safe and sufficient to induce DCM in rabbits. © 2012 Elsevier Ltd.en
dc.description.affiliationDivision of Veterinary Cardiology São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationDivision of Veterinary Pathology São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationDivision of Exact Sciences São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationUnespDivision of Veterinary Cardiology São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationUnespDivision of Veterinary Pathology São Paulo State University, Jaboticabal, São Paulo
dc.description.affiliationUnespDivision of Exact Sciences São Paulo State University, Jaboticabal, São Paulo
dc.format.extent115-121
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2012.07.027
dc.identifier.citationResearch in Veterinary Science, v. 94, n. 1, p. 115-121, 2013.
dc.identifier.doi10.1016/j.rvsc.2012.07.027
dc.identifier.issn0034-5288
dc.identifier.issn1532-2661
dc.identifier.scopus2-s2.0-84871485899
dc.identifier.urihttp://hdl.handle.net/11449/74481
dc.identifier.wosWOS:000319028000019
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.relation.ispartofjcr1.616
dc.relation.ispartofsjr0,593
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectDoxorubicin
dc.subjectEchocardiography
dc.subjectHistopathology
dc.subjectRabbits
dc.subjectScanning electron microscopy
dc.subjectdoxorubicin
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcardiotoxicity
dc.subjectcell death
dc.subjectcell degeneration
dc.subjectcell inclusion
dc.subjectcell vacuole
dc.subjectcongestive cardiomyopathy
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectfibrosing alveolitis
dc.subjectheart contraction
dc.subjectheart ejection fraction
dc.subjectheart left ventricle
dc.subjectheart ventricle septum
dc.subjecthistopathology
dc.subjectlymphocytic infiltration
dc.subjectmale
dc.subjectmortality
dc.subjectnonhuman
dc.subjectrabbit
dc.subjectscanning electron microscopy
dc.subjectsystolic dysfunction
dc.subjectAnimals
dc.subjectCardiomyopathy, Dilated
dc.subjectDisease Models, Animal
dc.subjectDose-Response Relationship, Drug
dc.subjectHeart
dc.subjectMale
dc.subjectMicroscopy, Electron
dc.subjectMicroscopy, Electron, Scanning
dc.subjectMyocardium
dc.subjectStroke Volume
dc.subjectAnimalia
dc.subjectOryctolagus cuniculus
dc.titleDoxorubicin induced dilated cardiomyopathy in a rabbit model: An updateen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes9642688764978907[8]
unesp.author.orcid0000-0001-9802-9271[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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