Comparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horses

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dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorAngeli, Ana L. [UNESP]
dc.contributor.authorFerreira, Cristiane L. [UNESP]
dc.contributor.authorLettry, Vivien [UNESP]
dc.contributor.authorScognamillo-Szabo, Marcia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2014-05-20T15:33:47Z
dc.date.available2014-05-20T15:33:47Z
dc.date.issued2008-09-01
dc.description.abstractPharmacopuncture, the injection of subclinical doses of drugs into acupoints reduces drug undesirable side effects, residues in animal consumption products and treatment costs in large animals. Acepromazine (Acp) produces several undesirable effects, such as hypotension. Previous studies with the injection of 1/10 of Acp dose in dog acupoints showed its advantage for sedation, minimizing undesirable effects. Eight horses were randomly submitted to four different treatment protocols according to a Latin Square double-blind design: (i) 0.1 ml kg(1) of saline subcutaneously injected at the cervical region, (ii) 0.1 mg kg(1) of Acp injected subcutaneously at the cervical region, (iii) 0.01 ml kg(1) of saline injected into GV1 acupoint (aquapuncture) and (iv) 0.01 mg kg(1) of Acp injected into GV1 acupoint (pharmacopuncture). Heart rate, respiratory rate, head height and degree of sedation were measured before and at 30, 60 and 90 min after treatments. Signs of sedation were observed in all treated groups at 30 min and only in 1/10Acp-GV1 at 60 min after the treatments. Only the group treated with 0.1 mg kg(1) of Acp s.c. had significantly lower values of head height at 30 min. Respiratory rate tended to reduce in all groups but was significantly lower only in horses treated with 0.1 mg kg(1) of Acp s.c. Heart rate remained unchanged in all groups. Acp-pharmacopuncture on GV1 in horses produced a mild sedation when compared with the conventional dose of Acp. More investigations are necessary to determine the optimal dosage of Acp-pharmacopuncture for sedation in horses.en
dc.description.affiliationSão Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Uberlandia, Fac Vet Med, BR-38400902 Uberlandia, MG, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Fac Vet Med & Anim Sci, BR-18618000 Botucatu, SP, Brazil
dc.format.extent267-272
dc.identifierhttp://dx.doi.org/10.1093/ecam/nel096
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. Oxford: Oxford Univ Press, v. 5, n. 3, p. 267-272, 2008.
dc.identifier.doi10.1093/ecam/nel096
dc.identifier.fileWOS000258961900006.pdf
dc.identifier.issn1741-427X
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.urihttp://hdl.handle.net/11449/42318
dc.identifier.wosWOS:000258961900006
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofjcr2.064
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectacupointen
dc.subjectacupunctureen
dc.subjectequineen
dc.subjectinjectionen
dc.subjectsedationen
dc.titleComparison of pharmacopuncture, aquapuncture and acepromazine for sedation of horsesen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderOxford Univ Press
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0001-5312-9076[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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