Increased susceptibility to development of anhedonia in rats with chronic peripheral nerve injury: Involvement of sleep deprivation?

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dc.contributor.authorAndersen, Monica L.
dc.contributor.authorHoshino, Katsumasa [UNESP]
dc.contributor.authorTufik, Sergio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:59Z
dc.date.available2014-05-20T13:49:59Z
dc.date.issued2009-08-31
dc.description.abstractThe Main purpose of the present study was to evaluate whether REM sleep deprivation (RSD) influences the development of anhedonia in rats in a peripheral neuropathy model induced by sciatic nerve constriction injury (CCI). Anhedonia was measured by assessing daily water/sucrose intake. Four groups were assessed: control (CTRL), CCI, RSD, and CCI + RSD (n = 8/group). Intake data were collected at baseline (mean of 3 days), on the 1st and 2nd days after a CCI or SHAM procedure, during 4 days of RSD, and during an additional 10 days (rebound period or equivalent in home-cage rats). Control rats spontaneously and progressively increased Sucrose intake, reaching final daily volumes significantly greater than respective initial baseline amounts. RSD promoted an additional and immediate significant increase in sucrose intake during sleep deprivation days. The CCI group did not display a spontaneous, progressive increase in sucrose intake. When CO was combined with RSD, the increase in sucrose intake induced by RSD was significantly lower than in animals submitted to RSD alone; the (CCI + RSD) group also failed to show a spontaneous and progressive increase in sucrose intake. The present findings indicate that animal model of chronic neuropathy exhibits reduced sucrose ingestion. Accordingly, this anhedonic condition that constitutes to the core manifestation of depressive states did not occur in response to a single episode of total RSD. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol Sci, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol Sci, São Paulo, Brazil
dc.description.sponsorshipAssociação Fundo de Incentivo a Psicofarmacologia (AFIP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 98/14303-3
dc.format.extent960-966
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2009.04.022
dc.identifier.citationProgress In Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 33, n. 6, p. 960-966, 2009.
dc.identifier.doi10.1016/j.pnpbp.2009.04.022
dc.identifier.issn0278-5846
dc.identifier.urihttp://hdl.handle.net/11449/17830
dc.identifier.wosWOS:000269300600007
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofProgress In Neuro-psychopharmacology & Biological Psychiatry
dc.relation.ispartofjcr4.185
dc.relation.ispartofsjr1,714
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnhedoniaen
dc.subjectPainen
dc.subjectRebounden
dc.subjectSciatic nerveen
dc.subjectSleep deprivationen
dc.subjectSucrose intakeen
dc.titleIncreased susceptibility to development of anhedonia in rats with chronic peripheral nerve injury: Involvement of sleep deprivation?en
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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