Chromosome 22q a frequent site of allele loss in head and neck carcinoma

Página do item simplificado
dc.contributor.authorPoli-Frederico, R. C.
dc.contributor.authorBergamo, N. A.
dc.contributor.authorReis, P. P.
dc.contributor.authorKowalski, L. P.
dc.contributor.authorZielenska, M.
dc.contributor.authorSquire, J. A.
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionA. C. Camargo Cancer Center
dc.contributor.institutionHospital for Sick Children
dc.contributor.institutionUniversity of Toronto
dc.date.accessioned2014-05-20T13:50:08Z
dc.date.available2014-05-20T13:50:08Z
dc.date.issued2000-09-01
dc.description.abstractBackground. Loss of heterozygosity (LOH) correlates with inactivated tumor suppressor genes. LOH at chromosome arm 22q has been found in a variety of human neoplasms, suggesting that this region contains a tumor suppressor gene(s) other than NF2 important to tumorigenesis. The aim of this study was to evaluate the presence of LOH on chromosome 22q11.2-13 and determine whether there was a relationship between loss in this genomic region and tumor histologic parameters, anatomic site, and survival in patients with squamous cell carcinoma of the head and neck (HNSCC).Methods. Fifty matched blood and HNSCC tumor samples taken at the time of surgical treatment were evaluated for LOH by use of four microsatellite markers mapping to 22q11.2-q13. Clinical information was available for all patients. The frequency and distribution of LOH was correlated with clinical (age, sex, use of tobacco and alcohol, site of primary tumor, clinical stage, adjuvant therapy and overall survival) and histologic parameters (histopathologic stage, tumor differentiation).Results. LOH at 22q was found in 19 of 50 (38%) informative tumors. The respective incidence of allelic loss for the patients was as follows: 28% at D22S421, 10% at D22S277, 8% at D22S44S, and 4% at D22S280. No statistical differences were apparent with a mean follow-up of 30 months. Laryngeal tumors showed a higher incidence of LOH compared with oral tumors.Conclusions. These results suggest that the D22S277 locus may be closely linked to a tumor suppressor gene (TSG) and involved in upper aerodigestive tract carcinogenesis. In particular, laryngeal tumors may harbor another putative TSG on 22q11.2-q12.3 that may play a role in aggressive stage III/IV disease. (C) 2000 John Wiley & Sons, Inc.en
dc.description.affiliationUNESP, IB, Dept Genet, Botucatu, SP, Brazil
dc.description.affiliationA C Camargo Hosp, São Paulo, Brazil
dc.description.affiliationHosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada
dc.description.affiliationUniv Toronto, Princess Margaret Hosp, Ontario Canc Inst, Fac Med,Dept Lab Med & Pathobiol, Toronto, ON, Canada
dc.description.affiliationUnespUNESP, IB, Dept Genet, Botucatu, SP, Brazil
dc.format.extent585-590
dc.identifierhttp://dx.doi.org/10.1002/1097-0347(200009)22:6<585
dc.identifier.citationHead and Neck-Journal For the Sciences and Specialties of the Head and Neck. New York: John Wiley & Sons Inc., v. 22, n. 6, p. 585-590, 2000.
dc.identifier.doi10.1002/1097-0347(200009)22:6<585
dc.identifier.issn1043-3074
dc.identifier.lattes1109525021631011
dc.identifier.orcid0000-0003-3775-3797
dc.identifier.urihttp://hdl.handle.net/11449/17896
dc.identifier.wosWOS:000088834500007
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofHead and Neck: Journal for the Sciences and Specialties of the Head and Neck
dc.relation.ispartofjcr2.471
dc.relation.ispartofsjr1,254
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthead and neck carcinomaspt
dc.subjectloss of heterozygositypt
dc.subjectchromosome 22pt
dc.subjectmicrosatellitespt
dc.titleChromosome 22q a frequent site of allele loss in head and neck carcinomaen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes1109525021631011[3]
unesp.author.orcid0000-0003-3775-3797[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Genética - IBB