Effect of menthol in experimentally induced ulcers: Pathways of gastroprotection

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dc.contributor.authorRozza, A. L. [UNESP]
dc.contributor.authorHiruma-Lima, C. A. [UNESP]
dc.contributor.authorTakahira, Regina Kiomi [UNESP]
dc.contributor.authorPadovani, C. R. [UNESP]
dc.contributor.authorPellizzon, C. H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:57Z
dc.date.available2014-12-03T13:10:57Z
dc.date.issued2013-11-25
dc.description.abstractBased on ethnopharmacological indications that Mentha species may be used in the treatment of gastrointestinal diseases, this study aimed to characterize the gastroprotective mechanisms of menthol (ME), the major compound of the essential oil from species of the genus Mentha. The gastroprotective action of ME was analyzed in gastric ulcers that were induced by ethanol or indomethacin in Wistar male rats. The mechanisms responsible for the gastroprotective effect were assessed by analyzing the amount of mucus secreted, involvement of non-protein sulfhydryl (NP-SH) compounds, involvement of calcium ion channels and NO/cGMP/K-ATP(+) pathway, gastric antisecretory activity and the prostaglandin E-2 (PGE(2)) production. The anti-diarrheal activity and acute toxicity of ME were also evaluated. Oral treatment with ME (50 mg/kg) offered 88.62% and 72.62% of gastroprotection against ethanol and indomethacin, respectively. There was an increased amount of mucus and PGE(2) production. The gastroprotective activity of ME involved NP-SH compounds and the stimulation of K-ATP(+) channels, but not the activation of calcium ion channels or the production of NO. The oral administration of ME induced an antisecretory effect as it decreased the H+ concentration in gastric juice. ME displayed anti-diarrheal and antiperistaltic activity. There were no signs of toxicity in the biochemical analyses performed in the rats' serum. These results demonstrated that ME provides gastroprotective and anti-diarrheal activities with no toxicity in rats. (C) 2013 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Vet Clin Dept, Sch Vet Med & Anim Sci FMVZ, Botucatu, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, Dept Physiol, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Vet Clin Dept, Sch Vet Med & Anim Sci FMVZ, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 10/08536-9
dc.format.extent272-278
dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2013.10.003
dc.identifier.citationChemico-biological Interactions. Clare: Elsevier Ireland Ltd, v. 206, n. 2, p. 272-278, 2013.
dc.identifier.doi10.1016/j.cbi.2013.10.003
dc.identifier.issn0009-2797
dc.identifier.lattes8727897080522289
dc.identifier.lattes0019393779801069
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0003-3323-4199
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.urihttp://hdl.handle.net/11449/112672
dc.identifier.wosWOS:000328523100019
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofChemico-biological Interactions
dc.relation.ispartofjcr3.296
dc.relation.ispartofsjr1,033
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMentholen
dc.subjectGastroprotectionen
dc.subjectGastric ulceren
dc.subjectDiarrheaen
dc.subjectAcute toxicityen
dc.titleEffect of menthol in experimentally induced ulcers: Pathways of gastroprotectionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes8727897080522289[4]
unesp.author.lattes2328604224911233[1]
unesp.author.lattes0019393779801069[5]
unesp.author.lattes3814504901386844[2]
unesp.author.orcid0000-0003-3323-4199[3]
unesp.author.orcid0000-0002-4198-0135[1]
unesp.author.orcid0000-0002-8645-3777[2]
unesp.author.orcid0000-0002-7719-9682[4]
unesp.author.orcid0000-0002-4494-4180[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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