Cardiorespiratory and antinociceptive effects of two different doses of lidocaine administered to horses during a constant intravenous infusion of xylazine and ketamine

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dc.contributor.authorNobrega Neto, Pedro I.
dc.contributor.authorLuna, Stélio Pacca Loureiro [UNESP]
dc.contributor.authorQueiroz-Williams, Patricia
dc.contributor.authorMama, Khursheed R.
dc.contributor.authorSteffey, Eugene P.
dc.contributor.authorCarregaro, Adriano B.
dc.contributor.institutionCampina Grande Fed Univ HRTC CGFU
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLouisiana State Univ
dc.contributor.institutionColorado State Univ
dc.contributor.institutionUniv Calif Davis
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:08:44Z
dc.date.available2014-12-03T13:08:44Z
dc.date.issued2013-10-09
dc.description.abstractBackground: This study investigated the antinociceptive effects of a constant rate infusion (CRI) of lidocaine during xylazine and ketamine anesthesia in horses and aimed to correlate these effects with cardiorespiratory variables, bispectral index (BIS) and plasma lidocaine concentrations. Six adult crossbred mares weighing 320-400 kg were anesthetized on three different occasions. Sedation was performed with xylazine (0.75 mg/kg IV) and anesthetic induction with guaifenesin (75 mg/kg IV) and ketamine (2 mg/kg IV). Anesthesia was maintained with 37.5 mu g/kg/min of xylazine and 87.5 mu g/kg/min of ketamine both administered intravenously for 75 min. The three treatments consisted of: lidocaine (loading dose: 5 mg/kg, CRI: 100 mu g/kg/min; THL); lidocaine (loading dose: 2.5 mg/kg; CRI: 50 mu g/kg/min: TLL); and saline (TS); all given 15 min after induction and maintained for 1 h. Antinociception was measured by response to electrical stimulation and bispectral index (BIS) was recorded during anesthesia. Parametric and non-parametric data were compared using ANOVA followed by Student-Newman-Keuls and Friedman tests, respectively.Results: Plasma lidocaine concentrations peaked at the end of lidocaine loading dose and was greater in THL (9.61 +/- 2.75 mu g/mL) vs TLL (4.50 +/- 3.34 mu g/mL). Electrical noxious stimulation caused purposeful movement in all horses from TS, but no response in THL. The BIS was decreased in THL only and was less when compared to the other treatments throughout anesthesia. Blood pressure, PaO2 and PaCO2 increased and heart rate (HR), respiratory rate (RR), pH, total plasma protein and temperature decreased during anesthesia in all treatments. PaCO2 and HR were greater and RR and pH less in THL compared to TLL and TS at 30 min during anesthesia. All recoveries were considered excellent. Time to standing was longer after THL (60 +/- 20 min) than following TLL and TS (32 +/- 17 and 30 +/- 15 min, respectively).Conclusions: At the highest dose administered (THL) lidocaine CRI during xylazine/ketamine anesthesia decreased BIS and motor response to noxious stimulation, and prolonged recovery time without significant added cardiorespiratory depression.en
dc.description.affiliationCampina Grande Fed Univ HRTC CGFU, Hlth & Rural Technol Ctr, Acad Unit Vet Med, Patos de Minas, Paraiba, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationLouisiana State Univ, Sch Vet Med, Dept Vet Clin Sci, Baton Rouge, LA 70803 USA
dc.description.affiliationColorado State Univ, Coll Vet Med & Biomed Sci, Dept Clin Sci, Ft Collins, CO 80523 USA
dc.description.affiliationUniv Calif Davis, Dept Surg & Radiol Sci, Davis, CA 95616 USA
dc.description.affiliationUniv Sao Paulo, Dept Vet Med, BR-13635900 Pirassununga, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618970 Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent9
dc.identifierhttp://dx.doi.org/10.1186/1746-6148-9-199
dc.identifier.citationBmc Veterinary Research. London: Biomed Central Ltd, v. 9, 9 p., 2013.
dc.identifier.doi10.1186/1746-6148-9-199
dc.identifier.fileWOS000326635500001.pdf
dc.identifier.issn1746-6148
dc.identifier.lattes4473260410099623
dc.identifier.orcid0000-0001-5312-9076
dc.identifier.urihttp://hdl.handle.net/11449/111524
dc.identifier.wosWOS:000326635500001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofBMC Veterinary Research
dc.relation.ispartofjcr1.958
dc.relation.ispartofsjr0,934
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAnesthesiaen
dc.subjectIntravenousen
dc.subjectBispectral indexen
dc.subjectElectroencephalographyen
dc.subjectAntinociceptionen
dc.subjectAnalgesiaen
dc.titleCardiorespiratory and antinociceptive effects of two different doses of lidocaine administered to horses during a constant intravenous infusion of xylazine and ketamineen
dc.typeArtigo
dcterms.rightsHolderBiomed Central Ltd
unesp.author.lattes4473260410099623
unesp.author.orcid0000-0002-0580-0467[6]
unesp.author.orcid0000-0001-5312-9076[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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